Science 6 December 1985: Vol. 230. no. 4730, pp. 1132 - 1139 DOI: 10.1126/science.2999974

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Articles

HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target.

C. Gravalos and A. Jimeno (2008)
Ann. Onc. 19, 1523-1529
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Young Age at Diagnosis Correlates With Worse Prognosis and Defines a Subset of Breast Cancers With Shared Patterns of Gene Expression.

C. K. Anders, D. S. Hsu, G. Broadwater, C. R. Acharya, J. A. Foekens, Y. Zhang, Y. Wang, P. K. Marcom, J. R. Marks, P. G. Febbo, et al. (2008)
J. Clin. Oncol. 26, 3324-3330
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Prognostic Value of the Molecular Detection of Circulating Tumor Cells Using a Multimarker Reverse Transcription-PCR Assay for Cytokeratin 19, Mammaglobin A, and HER2 in Early Breast Cancer.

M. Ignatiadis, G. Kallergi, M. Ntoulia, M. Perraki, S. Apostolaki, M. Kafousi, G. Chlouverakis, E. Stathopoulos, E. Lianidou, V. Georgoulias, et al. (2008)
Clin. Cancer Res. 14, 2593-2600
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Trastuzumab Activates Allogeneic or Autologous Antibody-Dependent Cellular Cytotoxicity against Malignant Rhabdoid Tumor Cells and Interleukin-2 Augments the Cytotoxicity.

Y. Katsumi, Y. Kuwahara, S. Tamura, K. Kikuchi, O. Otabe, K. Tsuchiya, T. Iehara, H. Kuroda, H. Hosoi, and T. Sugimoto (2008)
Clin. Cancer Res. 14, 1192-1199
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Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells.

C.-C. Ou, S.-C. Hsu, Y.-H. Hsieh, W.-L. Tsou, T.-C. Chuang, J.-Y. Liu, and M.-C. Kao (2008)
Carcinogenesis 29, 299-306
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Antibody and CD8+ T Cell Responses against HER2/neu Required for Tumor Eradication after DNA Immunization with a Flt-3 Ligand Fusion Vaccine.

F. Orlandi, F. M. Venanzi, A. Concetti, H. Yamauchi, S. Tiwari, L. Norton, J. D. Wolchok, A. N. Houghton, and P. D. Gregor (2007)
Clin. Cancer Res. 13, 6195-6203
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HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas.

S. A. V. Ricardo, F. Milanezi, S. T. Carvalho, D. R. A. Leitao, and F. C. L. Schmitt (2007)
J. Clin. Pathol. 60, 1001-1005
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A Polyepitope DNA Vaccine Targeted to Her-2/ErbB-2 Elicits a Broad Range of Human and Murine CTL Effectors to Protect against Tumor Challenge.

A. Scardino, M. Alimandi, P. Correale, S. G. Smith, R. Bei, H. Firat, M. G. Cusi, O. Faure, S. Graf-Dubois, G. Cencioni, et al. (2007)
Cancer Res. 67, 7028-7036
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Peptide Vaccines of the HER-2/neu Dimerization Loop Are Effective in Inhibiting Mammary Tumor Growth In Vivo.

S. D. Allen, J. T. Garrett, S. V. Rawale, A. L. Jones, G. Phillips, G. Forni, J. C. Morris, R. G. Oshima, and P. T. P. Kaumaya (2007)
J. Immunol. 179, 472-482
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Novel Engineered Trastuzumab Conformational Epitopes Demonstrate In Vitro and In Vivo Antitumor Properties against HER-2/neu.

J. T. Garrett, S. Rawale, S. D. Allen, G. Phillips, G. Forni, J. C. Morris, and P. T. P. Kaumaya (2007)
J. Immunol. 178, 7120-7131
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Increasing Anticarcinoma Activity of an Anti-erbB2 Recombinant Immunotoxin by the Addition of an Anti-EpCAM sFv.

B. J. Stish, H. Chen, Y. Shu, A. Panoskaltsis-Mortari, and D. A. Vallera (2007)
Clin. Cancer Res. 13, 3058-3067
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Brain Metastases: The HER2 Paradigm.

N. U. Lin and E. P. Winer (2007)
Clin. Cancer Res. 13, 1648-1655
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Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer.

X. Zhang and A. Chang (2007)
J. Med. Genet. 44, 166-172
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Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk.

K. Einarsdottir, K. Humphreys, C. Bonnard, Y. Li, Y. Li, K. S. Chia, E. T. Liu, P. Hall, J. Liu, and S. Wedren (2007)
Hum. Mol. Genet. 16, 154-164
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Levels of Specific Peptide-HLA Class I Complex Predicts Tumor Cell Susceptibility to CTL Killing.

J. A. Weidanz, T. Nguyen, T. Woodburn, F. A. Neethling, M. Chiriva-Internati, W. H. Hildebrand, and J. Lustgarten (2006)
J. Immunol. 177, 5088-5097
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Antitumor Effect of Trastuzumab for Pancreatic Cancer with High HER-2 Expression and Enhancement of Effect by Combined Therapy with Gemcitabine..

K. Kimura, T. Sawada, M. Komatsu, M. Inoue, K. Muguruma, T. Nishihara, Y. Yamashita, N. Yamada, M. Ohira, and K. Hirakawa (2006)
Clin. Cancer Res. 12, 4925-4932
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Early Tumor Response to Hsp90 Therapy Using HER2 PET: Comparison with 18F-FDG PET.

P. M. Smith-Jones, D. Solit, F. Afroze, N. Rosen, and S. M. Larson (2006)
J. Nucl. Med. 47, 793-796
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Cytokines fused to antibodies and their combinations as therapeutic agents against different peritoneal HER2/neu expressing tumors..

G. Helguera, J. A. Rodriguez, and M. L. Penichet (2006)
Mol. Cancer Ther. 5, 1029-1040
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A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor-{alpha} Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia.

T.-H. Huang and S. L. Morrison (2006)
J. Pharmacol. Exp. Ther. 316, 983-991
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Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors.

L. Albitar, L. L. Laidler, R. Abdallah, and K. K. Leslie (2005)
Mol. Cancer Ther. 4, 1891-1899
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Expression of HER2 and the Coamplified Genes GRB7 and MLN64 in Human Breast Cancer: Quantitative Real-time Reverse Transcription-PCR as a Diagnostic Alternative to Immunohistochemistry and Fluorescence In situ Hybridization.

U. Vinatzer, B. Dampier, B. Streubel, M. Pacher, M. J. Seewald, C. Stratowa, K. Kaserer, and M. Schreiber (2005)
Clin. Cancer Res. 11, 8348-8357
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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer..

M. J. Piccart-Gebhart, M. Procter, B. Leyland-Jones, A. Goldhirsch, M. Untch, I. Smith, L. Gianni, J. Baselga, R. Bell, C. Jackisch, et al. (2005)
N. Engl. J. Med. 353, 1659-1672
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Role of Chromogenic in Situ Hybridization (CISHTM) in the Evaluation of HER2 Status in Breast Carcinoma: Comparison with Immunohistochemistry and Fish.

E. Li-Ning-T, R. Ronchetti, C. Torres-Cabala, and M. J. Merino (2005)
International Journal of Surgical Pathology 13, 343-351
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Diagnostic Evaluation of HER-2 as a Molecular Target: An Assessment of Accuracy and Reproducibility of Laboratory Testing in Large, Prospective, Randomized Clinical Trials.

M. F. Press, G. Sauter, L. Bernstein, I. E. Villalobos, M. Mirlacher, J.-Y. Zhou, R. Wardeh, Y.-T. Li, R. Guzman, Y. Ma, et al. (2005)
Clin. Cancer Res. 11, 6598-6607
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A Bifunctional Targeted Peptide that Blocks HER-2 Tyrosine Kinase and Disables Mitochondrial Function in HER-2-Positive Carcinoma Cells.

V. R. Fantin, M. J. Berardi, H. Babbe, M. V. Michelman, C. M. Manning, and P. Leder (2005)
Cancer Res. 65, 6891-6900
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The immunocytokine scFv23/TNF sensitizes HER-2/neu-overexpressing SKBR-3 cells to tumor necrosis factor (TNF) via up-regulation of TNF receptor-1.

M.-A. Lyu and M. G. Rosenblum (2005)
Mol. Cancer Ther. 4, 1205-1213
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Trastuzumab-Mediated Antibody-Dependent Cellular Cytotoxicity against Esophageal Squamous Cell Carcinoma.

K. Mimura, K. Kono, M. Hanawa, M. Kanzaki, A. Nakao, A. Ooi, and H. Fujii (2005)
Clin. Cancer Res. 11, 4898-4904
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The epidermal growth factor receptor family.

L A Bazley and W J Gullick (2005)
Endocr. Relat. Cancer 12, S17-S27
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A monoclonal antibody against HER-2 (trastuzumab) for metastatic breast cancer: a model-based cost-effectiveness analysis.

J. Norum, T. Risberg, and J. A. Olsen (2005)
Ann. Onc. 16, 909-914
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Herceptin Down-Regulates HER-2/neu and Vascular Endothelial Growth Factor Expression and Enhances Taxol-Induced Cytotoxicity of Human Ewing's Sarcoma Cells In vitro and In vivo.

H. Guan, S.-F. Jia, Z. Zhou, J. Stewart, and E. S. Kleinerman (2005)
Clin. Cancer Res. 11, 2008-2017
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A Novel Peptide Isolated from a Phage Display Peptide Library with Trastuzumab Can Mimic Antigen Epitope of HER-2.

B. Jiang, W. Liu, H. Qu, L. Meng, S. Song, T. Ouyang, and C. Shou (2005)
J. Biol. Chem. 280, 4656-4662
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Conformational HER-2/neu B-cell Epitope Peptide Vaccine Designed to Incorporate Two Native Disulfide Bonds Enhances Tumor Cell Binding and Antitumor Activities.

N. K. Dakappagari, K. D. Lute, S. Rawale, J. T. Steele, S. D. Allen, G. Phillips, R. T. Reilly, and P. T. P. Kaumaya (2005)
J. Biol. Chem. 280, 54-63
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Her-2/neu Overexpression and Amplification in Uterine Papillary Serous Carcinoma.

B. M. Slomovitz, R. R. Broaddus, T. W. Burke, N. Sneige, P. T. Soliman, W. Wu, C. C. Sun, M. F. Munsell, D. M. Gershenson, and K. H. Lu (2004)
J. Clin. Oncol. 22, 3126-3132
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HER-2, gp100, and MAGE-1 Are Expressed in Human Glioblastoma and Recognized by Cytotoxic T Cells.

G. Liu, H. Ying, G. Zeng, C. J. Wheeler, K. L. Black, and J. S. Yu (2004)
Cancer Res. 64, 4980-4986
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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.

J. M. Swiercz, R. Kuner, and S. Offermanns (2004)
J. Cell Biol. 165, 869-880
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Radiolabeling, Biodistribution, and Dosimetry of 123I-mAb 14C5: A New mAb for Radioimmunodetection of Tumor Growth and Metastasis In Vivo.

C. M.M. Lahorte, K. Bacher, I. Burvenich, E. D. Coene, C. Cuvelier, C. De Potter, H. Thierens, C. Van de Wiele, R. A. Dierckx, and G. Slegers (2004)
J. Nucl. Med. 45, 1065-1073
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High resolution microarray comparative genomic hybridisation analysis using spotted oligonucleotides.

B Carvalho, E Ouwerkerk, G A Meijer, and B Ylstra (2004)
J. Clin. Pathol. 57, 644-646
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Caspase-8-Dependent HER-2 Cleavage in Response to Tumor Necrosis Factor {alpha} Stimulation Is Counteracted by Nuclear Factor {kappa}B through c-FLIP-L Expression.

V. Benoit, A. Chariot, L. Delacroix, V. Deregowski, N. Jacobs, M.-P. Merville, and V. Bours (2004)
Cancer Res. 64, 2684-2691
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Treatment of HER-2/neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction.

C. Warburton, W. H. Dragowska, K. Gelmon, S. Chia, H. Yan, D. Masin, T. Denyssevych, A. E. Wallis, and M. B. Bally (2004)
Clin. Cancer Res. 10, 2512-2524
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Trastuzumab (Herceptin) Enhances Class I-Restricted Antigen Presentation Recognized by HER-2/neu-Specific T Cytotoxic Lymphocytes.

K. Kono, E. Sato, H. Naganuma, A. Takahashi, K. Mimura, H. Nukui, and H. Fujii (2004)
Clin. Cancer Res. 10, 2538-2544
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Negative Regulation of HER2 Signaling by the PEST-type Protein-tyrosine Phosphatase BDP1.

M. Gensler, M. Buschbeck, and A. Ullrich (2004)
J. Biol. Chem. 279, 12110-12116
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The N-terminal Region of NTAK/Neuregulin-2 Isoforms Has an Inhibitory Activity on Angiogenesis.

N. Nakano, S. Higashiyama, H. Ohmoto, H. Ishiguro, N. Taniguchi, and Y. Wada (2004)
J. Biol. Chem. 279, 11465-11470
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Monitoring of Serum Her-2/neu Predicts Response and Progression-Free Survival to Trastuzumab-Based Treatment in Patients with Metastatic Breast Cancer.

W. J. Kostler, B. Schwab, C. F. Singer, R. Neumann, E. Rucklinger, T. Brodowicz, S. Tomek, M. Niedermayr, M. Hejna, G. G. Steger, et al. (2004)
Clin. Cancer Res. 10, 1618-1624
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HER2 Expression in Salivary Gland Carcinomas: Dependence on Histological Subtype.

B. Glisson, A. D. Colevas, R. Haddad, J. Krane, A. El-Naggar, M. Kies, R. Costello, C. Summey, M. Arquette, C. Langer, et al. (2004)
Clin. Cancer Res. 10, 944-946
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Clinical Cardiac Tolerability of Trastuzumab.

E. A. Perez and R. Rodeheffer (2004)
J. Clin. Oncol. 22, 322-329
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HER-2/neu-Mediated Regulation of Components of the MHC Class I Antigen-Processing Pathway.

F. Herrmann, H.-A. Lehr, I. Drexler, G. Sutter, J. Hengstler, U. Wollscheid, and B. Seliger (2004)
Cancer Res. 64, 215-220
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Expression of the c-ErbB-2/HER2 proto-oncogene in normal hematopoietic cells.

F. Leone, E. Perissinotto, G. Cavalloni, V. Fonsato, S. Bruno, N. Surrenti, D. Hong, A. Capaldi, M. Geuna, W. Piacibello, et al. (2003)
J. Leukoc. Biol. 74, 593-601
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Potential Clinical Utility of Serum HER-2/neu Oncoprotein Concentrations in Patients with Breast Cancer.

W. P. Carney, R. Neumann, A. Lipton, K. Leitzel, S. Ali, and C. P. Price (2003)
Clin. Chem. 49, 1579-1598
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Gene Expression Profiling of Neu-induced Mammary Tumors from Transgenic Mice Reveals Genetic and Morphological Similarities to ErbB2-expressing Human Breast Cancers.

E. R. Andrechek, M. A. Laing, A. A. Girgis-Gabardo, P. M. Siegel, R. D. Cardiff, and W. J. Muller (2003)
Cancer Res. 63, 4920-4926
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Comparison of Two Quantitative Polymerase Chain Reaction Methods for Detecting HER2/neu Amplification.

A. Millson, A. Suli, L. Hartung, S. Kunitake, A. Bennett, M. C. L. Nordberg, W. Hanna, C. T. Wittwer, A. Seth, and E. Lyon (2003)
J. Mol. Diagn. 5, 184-190
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Trastuzumab and Interleukin-2 in HER2-positive Metastatic Breast Cancer: A Pilot Study.

T. Repka, E. G. Chiorean, J. Gay, K. E. Herwig, V. K. Kohl, D. Yee, and J. S. Miller (2003)
Clin. Cancer Res. 9, 2440-2446
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic Significance of p53, nm23, PCNA and c-erbB-2 in Gastric Cancer.

K. E. Lee, H.-J. Lee, Y. H. Kim, H. J. Yu, H.-K. Yang, W.-H. Kim, K. U. Lee, K. J. Choe, and J.-P. Kim (2003)
Jpn. J. Clin. Oncol. 33, 173-179
 |  Abstract »  |  Full Text »  |  PDF »

Human Epidermal Receptor-2 Expression in Prostate Cancer.

B. F. Calvo, A. M. Levine, M. Marcos, Q. F. Collins, M. V. Iacocca, L. S. Caskey, C. W. Gregory, Y. Lin, Y. E. Whang, H. S. Earp, et al. (2003)
Clin. Cancer Res. 9, 1087-1097
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Growth Factor Receptors in Breast Cancer: Potential for Therapeutic Intervention.

R. Nahta, G. N. Hortobagyi, and F. J. Esteva (2003)
Oncologist 8, 5-17
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Active Signaling by HER-2/neu in a Subpopulation of HER-2/neu-overexpressing Ductal Carcinoma in Situ: Clinicopathological Correlates.

M. P. DiGiovanna, P. Chu, T. L. Davison, C. L. Howe, D. Carter, E. B. Claus, and D. F. Stern (2002)
Cancer Res. 62, 6667-6673
 |  Abstract »  |  Full Text »  |  PDF »

In vitro comparative evaluation of trastuzumab (Herceptin(R)) combined with paclitaxel (Taxol(R)) or docetaxel (Taxotere(R)) in HER2-expressing human breast cancer cell lines.

J.-L. Merlin, M. Barberi-Heyob, and N. Bachmann (2002)
Ann. Onc. 13, 1743-1748
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells Pulsed with HER-2/neu-derived Peptides Can Induce Specific T-Cell Responses in Patients with Gastric Cancer.

K. Kono, A. Takahashi, H. Sugai, H. Fujii, A. R. Choudhury, R. Kiessling, and Y. Matsumoto (2002)
Clin. Cancer Res. 8, 3394-3400
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of Effective Tumor Targeting by CD8+ Natural Killer T Cells Redirected with Bispecific Antibody F(ab')2HER2xCD3.

C. Scheffold, M. Kornacker, Y. C. Scheffold, C. H. Contag, and R. S. Negrin (2002)
Cancer Res. 62, 5785-5791
 |  Abstract »  |  Full Text »  |  PDF »

c-erb B-2 Expression Is Associated with Tumor Location and Venous Invasion and Influences Survival of Patients with Gastric Carcinoma.

J. Pinto-de-Sousa, L. David, R. Almeida, D. Leitao, J. R. Preto, M. Seixas, and A. Pimenta (2002)
International Journal of Surgical Pathology 10, 247-256
 |  Abstract »  |  PDF »

Basolateral Targeting of ERBB2 Is Dependent on a Novel Bipartite Juxtamembrane Sorting Signal but Independent of the C-Terminal ERBIN-Binding Domain.

C. Dillon, A. Creer, K. Kerr, A. Kumin, and C. Dickson (2002)
Mol. Cell. Biol. 22, 6553-6563
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of HER-2/neu Gene Amplification and Overexpression: Comparison of Frequently Used Assay Methods in a Molecularly Characterized Cohort of Breast Cancer Specimens.

M. F. Press, D. J. Slamon, K. J. Flom, J. Park, J.-Y. Zhou, and L. Bernstein (2002)
J. Clin. Oncol. 20, 3095-3105
 |  Abstract »  |  Full Text »  |  PDF »

ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival.

E. R. Andrechek, W. R. Hardy, A. A. Girgis-Gabardo, R. L. S. Perry, R. Butler, F. L. Graham, R. C. Kahn, M. A. Rudnicki, and W. J. Muller (2002)
Mol. Cell. Biol. 22, 4714-4722
 |  Abstract »  |  Full Text »  |  PDF »

"Build Quality in"--HER2 Testing in the Real World.

J. A. Zujewski (2002)
J Natl Cancer Inst 94, 788-789
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Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay.

G. Curigliano, M. Colleoni, G. Renne, G. Mazzarol, R. Gennari, G. Peruzzotti, F. de Braud, C. Robertson, E. Maiorano, P. Veronesi, et al. (2002)
Ann. Onc. 13, 895-902
 |  Abstract »  |  Full Text »  |  PDF »

Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide-Based Vaccines.

M. L. Disis, T. A. Gooley, K. Rinn, D. Davis, M. Piepkorn, M. A. Cheever, K. L. Knutson, and K. Schiffman (2002)
J. Clin. Oncol. 20, 2624-2632
 |  Abstract »  |  Full Text »  |  PDF »

A New Human Antitumor Immunoreagent Specific for ErbB2.

C. De Lorenzo, D. B. Palmer, R. Piccoli, M. A. Ritter, and G. D'Alessio (2002)
Clin. Cancer Res. 8, 1710-1719
 |  Abstract »  |  Full Text »  |  PDF »

HER-2/neu and hTERT Cryptic Epitopes as Novel Targets for Broad Spectrum Tumor Immunotherapy.

A. Scardino, D.-A. Gross, P. Alves, J. L. Schultze, S. Graff-Dubois, O. Faure, S. Tourdot, S. Chouaib, L. M. Nadler, F. A. Lemonnier, et al. (2002)
J. Immunol. 168, 5900-5906
 |  Abstract »  |  Full Text »  |  PDF »

Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

M M de Jong, I M Nolte, G J te Meerman, W T A van der Graaf, J C Oosterwijk, J H Kleibeuker, M Schaapveld, and E G E de Vries (2002)
J. Med. Genet. 39, 225-242
 |  Abstract »  |  Full Text »  |  PDF »

Early Placenta Insulin-like Growth Factor (pro-EPIL) Is Overexpressed and Secreted by c-erbB-2-positive Cells with High Invasion Potential.

B. Brandt, A. Roetger, J.-M. Bidart, J. Packeisen, K. Schier, J.-H. Mikesch, D. Kemming, W. Boecker, D. Yu, and H. Buerger (2002)
Cancer Res. 62, 1020-1024
 |  Abstract »  |  Full Text »  |  PDF »

Automated Electrorotation to Reveal Dielectric Variations Related to HER-2/neu Overexpression in MCF-7 Sublines.

M. Cristofanilli, G. De Gasperis, L. Zhang, M.-C. Hung, P. R. C. Gascoyne, and G. N. Hortobagyi (2002)
Clin. Cancer Res. 8, 615-619
 |  Abstract »  |  Full Text »  |  PDF »

Significance of, and Optimal Screening for, HER-2 Gene Amplification and Protein Overexpression in Breast Carcinoma.

W. K. Funkhouser and K. Kaiser-Rogers (2001)
Ann. Clin. Lab. Sci. 31, 349-358
 |  Abstract »  |  Full Text »  |  PDF »

RRR-{alpha}-Tocopheryl Succinate Induces MDA-MB-435 and MCF-7 Human Breast Cancer Cells to Undergo Differentiation.

H. You, W. Yu, B. G. Sanders, and K. Kline (2001)
Cell Growth Differ. 12, 471-480
 |  Abstract »  |  Full Text »  |  PDF »

Is Circulating HER-2 More Than Just a Tumor Marker?.

J. Baselga (2001)
Clin. Cancer Res. 7, 2605-2607
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Her-2/neu Overexpression in Muscle-invasive Urothelial Carcinoma of the Bladder: Prognostic Significance and Comparative Analysis in Primary and Metastatic Tumors.

R. E. Jimenez, M. Hussain, F. J. Bianco Jr., U. Vaishampayan, P. Tabazcka, W. A. Sakr, J. E. Pontes, D. P. Wood Jr., and D. J. Grignon (2001)
Clin. Cancer Res. 7, 2440-2447
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Novel Compounds in the Therapy of Breast Cancer: Opportunities for Integration with Docetaxel.

A. W. Tolcher (2001)
Oncologist 6, 40-44
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Weekly Trastuzumab and Paclitaxel Therapy for Metastatic Breast Cancer With Analysis of Efficacy by HER2 Immunophenotype and Gene Amplification.

A. D. Seidman, M. N. Fornier, F. J. Esteva, L. Tan, S. Kaptain, A. Bach, K. S. Panageas, C. Arroyo, V. Valero, V. Currie, et al. (2001)
J. Clin. Oncol. 19, 2587-2595
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Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR.

Y. Yu, A. K. Rishi, J. R. Turner, D. Liu, E. D. Black, J. A. Moshier, and A. P. N. Majumdar (2001)
Am J Physiol Cell Physiol 280, C1083-C1089
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Identification of Epitope Regions Recognized by Tumor Inhibitory and Stimulatory Anti-ErbB-2 Monoclonal Antibodies: Implications for Vaccine Design.

Y. L. Yip, G. Smith, J. Koch, S. Dubel, and R. L. Ward (2001)
J. Immunol. 166, 5271-5278
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Comparison of Methods of Measuring HER-2 in Metastatic Breast Cancer Patients Treated With High-Dose Chemotherapy.

L. N. Harris, V. Liotcheva, G. Broadwater, M. J. Ramirez, P. Maimonis, S. Anderson, T. Everett, D. Harpole, M. B. Moore, D. A. Berry, et al. (2001)
J. Clin. Oncol. 19, 1698-1706
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Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2.

D. J. Slamon, B. Leyland-Jones, S. Shak, H. Fuchs, V. Paton, A. Bajamonde, T. Fleming, W. Eiermann, J. Wolter, M. Pegram, et al. (2001)
N. Engl. J. Med. 344, 783-792
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erbB2 Overexpression on Occult Metastatic Cells in Bone Marrow Predicts Poor Clinical Outcome of Stage I-III Breast Cancer Patients.

S. Braun, G. Schlimok, I. Heumos, G. Schaller, L. Riethdorf, G. Riethmüller, and K. Pantel (2001)
Cancer Res. 61, 1890-1895
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Overexpression of HER-2 in Ovarian Carcinomas.

I. Hellström, G. Goodman, J. Pullman, Y. Yang, and K. E. Hellström (2001)
Cancer Res. 61, 2420-2423
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The Association of HER-2/neu Amplification With Breast Cancer Recurrence.

J. A. Carr, S. Havstad, R. J. Zarbo, G. Divine, P. Mackowiak, and V. Velanovich (2000)
Arch Surg 135, 1469-1474
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Recombinant Anti-Human HER2/neu IgG3-(GM-CSF) Fusion Protein Retains Antigen Specificity and Cytokine Function and Demonstrates Antitumor Activity.

J. S. Dela Cruz, K. R. Trinh, S. L. Morrison, and M. L. Penichet (2000)
J. Immunol. 165, 5112-5121
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