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Science 29 November 1985:
Vol. 230. no. 4729, pp. 1035 - 1037
DOI: 10.1126/science.2997929
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Articles

Science, Vol 230, Issue 4729, 1035-1037
Copyright © 1985 by American Association for the Advancement of Science

articles

Corticotropin-releasing activity of monokines

BM Woloski, EM Smith, WJ Meyer 3rd, GM Fuller, and JE Blalock

Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.


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