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Science 22 November 1985:
Vol. 230. no. 4728, pp. 954 - 958
DOI: 10.1126/science.2997924
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Articles

Science, Vol 230, Issue 4728, 954-958
Copyright © 1985 by American Association for the Advancement of Science

articles

Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination

P Bullock, JJ Champoux, and M Botchan

Nonhomologous DNA recombination is frequently observed in somatic cells upon the introduction of DNA into cells or in chromosomal events involving sequences already stably carried by the genome. In this report, the DNA sequences at the crossover points for excision of SV40 from chromosomes were shown to be associated with eukaryotic topoisomerase I cleavage sites in vitro. The precise location of the cleavage sites relative to the crossover points has suggested a general model for nonhomologous recombination mediated by topoisomerase I.


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