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Science 22 November 1985:
Vol. 230. no. 4728, pp. 951 - 954
DOI: 10.1126/science.2997923
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Articles

Science, Vol 230, Issue 4728, 951-954
Copyright © 1985 by American Association for the Advancement of Science

articles

Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys

PJ Kanki, J Alroy, and M Essex

Present evidence suggests that the acquired immune deficiency syndrome (AIDS) emerged in Central Africa as a new disease in recent decades. This disease has recently approached epidemic proportions in many parts of the world. The etiologic agent of AIDS is believed to be the virus HTLV-III/LAV, which has been proposed as having originated from a recent simian-human transmission in Africa. This report describes the isolation of a designated STLV-IIIAGM retrovirus closely related to HTLV-III/LAV from seven healthy wild-caught African Green monkeys (Cercopithecus aethiops) that showed the presence of antibodies designated STLV-IIIAGM. In vitro growth characteristics, ultrastructural morphology, and major proteins of 160,000 kilodaltons (kD), 120 kD, 55 kD, and 24 kD are similar to and cross-reactive with the analogous antigens of HTLV-III/LAV. The use of these serologic markers in the detection of STLV-IIIAGM-infected monkeys may be important in assuring the continued safety of a variety of biologic reagents that are derived from these primate species. The existence of a retrovirus closely related to HTLV-III/LAV that naturally infects an African nonhuman primate in the apparent absence of disease may provide a unique model for the study of human AIDS and the development of an effective vaccine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys.
J.-M. Lozano Reina, D. Favre, Z. Kasakow, V. Mayau, M.-T. Nugeyre, T. Ka, A. Faye, C. J. Miller, D. Scott-Algara, J. M. McCune, et al. (2009)
J. Virol. 83, 2770-2777
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Engineered CD4- and CXCR4-Using Simian Immunodeficiency Virus from African Green Monkeys Is Neutralization Sensitive and Replicates in Nonstimulated Lymphocytes.
R. R. Konig, E. Flory, S. Steidl, J. Neumann, C. Coulibaly, E. Holznagel, S. Holzammer, S. Norley, and K. Cichutek (2002)
J. Virol. 76, 10627-10636
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Patterns of Genomic Sequence Diversity among Their Simian Immunodeficiency Viruses Suggest that L'Hoest Monkeys (Cercopithecus lhoesti) Are a Natural Lentivirus Reservoir.
B. E. Beer, E. Bailes, G. Dapolito, B. J. Campbell, R. M. Goeken, M. K. Axthelm, P. D. Markham, J. Bernard, D. Zagury, G. Franchini, et al. (2000)
J. Virol. 74, 3892-3898
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The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm.
S. Wagener, M. T. Dittmar, B. Beer, R. Konig, R. Plesker, S. Norley, R. Kurth, and K. Cichutek (1998)
J. Virol. 72, 3446-3450
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Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.
L. Henderson, R. Sowder, T. Copeland, R. Benveniste, and S Oroszlan (1988)
Science 241, 199-201
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The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
A. Fauci (1988)
Science 239, 617-622
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A quantitative bioassay for HIV-1 based on trans-activation.
B. Felber and G. Pavlakis (1988)
Science 239, 184-187
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Functional interaction and partial homology between human immunodeficiency virus and neuroleukin.
M. Lee, D. Ho, and M. Gurney (1987)
Science 237, 1047-1051
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Human T-lymphotropic virus type 4 and the human immunodeficiency virus in West Africa.
P. Kanki, S M'Boup, D Ricard, F Barin, F Denis, C Boye, L Sangare, K Travers, M Albaum, R Marlink, et al. (1987)
Science 236, 827-831
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Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.
N. Pedersen, E. Ho, M. Brown, and J. Yamamoto (1987)
Science 235, 790-793
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AIDS in Africa: an epidemiologic paradigm.
T. Quinn, J. Mann, J. Curran, and P Piot (1986)
Science 234, 955-963
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Detection of HTLV-III RNA in Lungs of Patients With AIDS and Pulmonary Involvement.
K. J. Chayt, M. E. Harper, L. M. Marselle, E. B. Lewin, R. M. Rose, J. M. Oleske, L. G. Epstein, F. Wong-Staal, and R. C. Gallo (1986)
JAMA 256, 2356-2359
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Isolation of a new human retrovirus from West African patients with AIDS.
F Clavel, D Guetard, F Brun-Vezinet, S Chamaret, M. Rey, M. Santos-Ferreira, A. Laurent, C Dauguet, C Katlama, C Rouzioux, et al. (1986)
Science 233, 343-346
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New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
P. Kanki, F Barin, S M'Boup, J. Allan, J. Romet-Lemonne, R Marlink, M. McLane, T. Lee, B Arbeille, F Denis, et al. (1986)
Science 232, 238-243
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AIDS, Social Sciences, and Health Education: A Personal Perspective.
J. E. Osborn (1986)
Health Educ Behav 13, 287-299
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Africa and the origin of AIDS.
C Norman (1985)
Science 230, 1141
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