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Science 22 November 1985: Vol. 230. no. 4728, pp. 943 - 945 DOI: 10.1126/science.3933111
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Articles
Science, Vol 230, Issue 4728, 943-945
Copyright © 1985 by American Association for the Advancement of Science
Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro
BJ Sugarman,
BB Aggarwal,
PE Hass,
IS Figari,
MA Palladino Jr,
and
HM Shepard
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated. rTNF-alpha had cytostatic or cytolytic effects on only some tumor cell lines. When administered together with rIFN-gamma, rTNF-alpha showed enhanced antiproliferative effects on a subset of the cell lines tested. In contrast to its effects on sensitive tumor cells, rTNF-alpha augmented the growth of normal diploid fibroblasts. Variations in the proliferative response induced by rTNF-alpha were apparently not due to differences in either the number of binding sites per cell or their affinity for rTNF-alpha. These observations indicate that the effects of rTNF-alpha on cell growth are not limited to tumor cells, but rather that this protein may have a broad spectrum of activities in vivo.
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| Abstract »
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| Full Text »
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| Abstract »
| Full Text »
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- C. Lamblin, C. Bergoin, T. Saelens, and B. Wallaert (2001)
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
| PDF »
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- V N Foltyn and T D Golan (2001)
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| Abstract »
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| Abstract »
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- S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal (2000)
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165, 4927-4934
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- M. E. Rosenfeld, L. Prichard, N. Shiojiri, and N. Fausto (2000)
Am. J. Pathol.
156, 997-1007
| Abstract »
| Full Text »
| PDF »
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- M. H. J. Vogt, R. A. de Paus, P. J. Voogt, R. Willemze, and J. H. F. Falkenburg (2000)
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| Abstract »
| Full Text »
| PDF »
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- Y. Wen, D.-H. Yan, B. Spohn, J. Deng, S.-Y. Lin, and M.-C. Hung (2000)
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| Abstract »
| Full Text »
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- X.-F. Le, A. McWatters, J. Wiener, J.-Y. Wu, G. B. Mills, and R. C. Bast Jr. (2000)
Clin. Cancer Res.
6, 260-270
| Abstract »
| Full Text »
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- J. Matsuzaki, R. Yamaji, K. Kiyomiya, M. Kurebe, H. Inui, and Y. Nakano (2000)
J. Nutr.
130, 111-115
| Abstract »
| Full Text »
- Resistance to the Cytotoxic Effects of Tumor Necrosis Factor alpha Can Be Overcome by Inhibition of a FADD/Caspase-dependent Signaling Pathway.
- A. Khwaja and L. Tatton (1999)
J. Biol. Chem.
274, 36817-36823
| Abstract »
| Full Text »
| PDF »
- Specificity of endogenous fatty acid release during tumor necrosis factor-induced apoptosis in WEHI 164 fibrosarcoma cells.
- O.-L. Brekke, E. Sagen, and K. S. Bjerve (1999)
J. Lipid Res.
40, 2223-2233
| Abstract »
| Full Text »
| PDF »
- Activation of Sphingosine Kinase by Tumor Necrosis Factor-alpha Inhibits Apoptosis in Human Endothelial Cells.
- P. Xia, L. Wang, J. R. Gamble, and M. A. Vadas (1999)
J. Biol. Chem.
274, 34499-34505
| Abstract »
| Full Text »
| PDF »
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- J. Theys, S. Nuyts, W. Landuyt, L. Van Mellaert, C. Dillen, M. Böhringer, P. Dürre, P. Lambin, and J. Anné (1999)
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65, 4295-4300
| Abstract »
| Full Text »
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- X. Hu, M. Tang, A. B. Fisher, N. Olashaw, and K. S. Zuckerman (1999)
J. Immunol.
163, 3106-3115
| Abstract »
| Full Text »
| PDF »
- Inhibition of Nuclear Factor-{{kappa}}B Activation Confers Sensitivity to Tumor Necrosis Factor-{{alpha}} by Impairment of Cell Cycle Progression in Human Glioma Cells.
- G. Otsuka, T. Nagaya, K. Saito, M. Mizuno, J. Yoshida, and H. Seo (1999)
Cancer Res.
59, 4446-4452
| Abstract »
| Full Text »
| PDF »
- Mast Cells in Rapidly Progressive Glomerulonephritis.
- T. TÓTH, R. TÓTH-JAKATICS, S. JIMI, M. IHARA, H. URATA, and S. TAKEBAYASHI (1999)
J. Am. Soc. Nephrol.
10, 1498-1505
| Abstract »
| Full Text »
- Identification and Characterization of a Novel Cytokine, THANK, a TNF Homologue That Activates Apoptosis, Nuclear Factor-kappa B, and c-Jun NH2-Terminal Kinase.
- A. Mukhopadhyay, J. Ni, Y. Zhai, G.-L. Yu, and B. B. Aggarwal (1999)
J. Biol. Chem.
274, 15978-15981
| Abstract »
| Full Text »
| PDF »
- A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment.
- F. Myokai, S. Takashiba, R. Lebo, and S. Amar (1999)
PNAS
96, 4518-4523
| Abstract »
| Full Text »
| PDF »
- Tumor necrosis factor-alpha and ceramide induce cell death through different mechanisms in rat mesangial cells.
- Y.-L. Guo, B. Kang, L.-J. Yang, and J. R. Williamson (1999)
Am J Physiol Renal Physiol
276, F390-F397
| Abstract »
| Full Text »
| PDF »
- Resistance to TNF-alpha cytotoxicity can be achieved through different signaling pathways in rat mesangial cells.
- Y.-L. Guo, B. Kang, and J. R. Williamson (1999)
Am J Physiol Cell Physiol
276, C435-C441
| Abstract »
| Full Text »
| PDF »
- Interleukin-12 Induces an Effective Antitumor Response in Malignant Mesothelioma.
- I. Caminschi, E. Venetsanakos, C. C. Leong, M. J. Garlepp, B. Scott, and B. W. S. Robinson (1998)
Am. J. Respir. Cell Mol. Biol.
19, 738-746
| Abstract »
| Full Text »
- Sustained Phosphorylation of Cytosolic Phospholipase A2 Accompanies Cycloheximide- and Adenovirus-Induced Susceptibility to TNF.
- J. B. O'Brien, D. L. Piddington, C. Voelkel-Johnson, D. J. Richards, L. A. Hadley, and S. M. Laster (1998)
J. Immunol.
161, 1525-1532
| Abstract »
| Full Text »
| PDF »
- Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha , as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells.
- N. Mizushima, H. Kohsaka, and N. Miyasaka (1998)
Ann Rheum Dis
57, 495-499
| Abstract »
| Full Text »
- Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-alpha in Rat Mesangial Cells.
- Y.-L. Guo, B. Kang, and J. R. Williamson (1998)
J. Biol. Chem.
273, 10362-10366
| Abstract »
| Full Text »
| PDF »
- Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-alpha in Rat Mesangial Cells.
- Y.-L. Guo, K. Baysal, B. Kang, L.-J. Yang, and J. R. Williamson (1998)
J. Biol. Chem.
273, 4027-4034
| Abstract »
| Full Text »
| PDF »
- The Involvement of Novel Protein Kinase C Isozymes in Influencing Sensitivity of Breast Cancer MCF-7 Cells to Tumor Necrosis Factor-alpha.
- A. Basu (1998)
Mol. Pharmacol.
53, 105-111
| Abstract »
| Full Text »
- Interferon-gamma induces a decrease in the intracellular calcium pump in a human salivary gland cell line.
- S. Meehan, A. J. Wu, E. C. Kang, T. Sakai, and I. S. Ambudkar (1997)
Am J Physiol Cell Physiol
273, C2030-C2036
| Abstract »
| Full Text »
| PDF »
- The Epidermal Growth Factor Receptor Is Not Required for Tumor Necrosis Factor-{alpha} Action in Normal Mammary Epithelial Cells.
- L. M. Varela, K. M. Darcy, and M. M. Ip (1997)
Endocrinology
138, 3891-3900
| Abstract »
| Full Text »
| PDF »
- Interleukin-4 and -13 Inhibit Tumor Necrosis Factor-alpha mRNA Translational Activation in Lipopolysaccharide-induced Mouse Macrophages.
- T. Mijatovic, V. Kruys, D. Caput, P. Defrance, and G. Huez (1997)
J. Biol. Chem.
272, 14394-14398
| Abstract »
| Full Text »
| PDF »
- Increased release of tumour necrosis factor-alpha in human tear fluid after excimer laser induced corneal wound.
- M. Vesaluoma, A.-M. Teppo, C. Gronhagen-Riska, and T. Tervo (1997)
Br J Ophthalmol
81, 145-149
| Abstract »
| Full Text »
| PDF »
- Inducible Activation of RelB in Fibroblasts.
- N. E. Olashaw and N. E. Olashaw (1996)
J. Biol. Chem.
271, 30307-30310
| Abstract »
| Full Text »
| PDF »
- Endothelial Cell Death Induced by Tumor Necrosis Factor-alpha Is Inhibited by the Bcl-2 Family Member, A1.
- A. Karsan, E. Yee, and J. M. Harlan (1996)
J. Biol. Chem.
271, 27201-27204
| Abstract »
| Full Text »
| PDF »
- Myxoma Virus T2 Protein, a Tumor Necrosis Factor (TNF) Receptor Homolog, Is Secreted as a Monomer and Dimer That Each Bind Rabbit TNFalpha , but the Dimer Is a More Potent TNF Inhibitor.
- M. Schreiber, K. Rajarathnam, and G. McFadden (1996)
J. Biol. Chem.
271, 13333-13341
| Abstract »
| Full Text »
| PDF »
- Apoptotic Inhibition of Head and Neck Squamous Cell Carcinoma Cells by Tumor Necrosis Factor {alpha}.
- K. B. Briskin, C. Fady, M. Wang, and A. Lichtenstein (1996)
Arch Otolaryngol Head Neck Surg
122, 559-563
| Abstract »
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- Plasminogen Activator Inhibitor Type 2 Inhibits Tumor Necrosis Factor alpha-induced Apoptosis.
- J. L. Dickinson, E. J. Bates, A. Ferrante, and T. M. Antalis (1995)
J. Biol. Chem.
270, 27894-27904
| Abstract »
| Full Text »
| PDF »
- Effects of Tumor Necrosis Factor-alpha on Antimitogenicity and Cell Cycle-related Proteins in MCF-7 Cells.
- D.-i. Jeoung, B. Tang, and M. Sonenberg (1995)
J. Biol. Chem.
270, 18367-18373
| Abstract »
| Full Text »
| PDF »
- Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes.
- Y. Y. C. Lo and T. F. Cruz (1995)
J. Biol. Chem.
270, 11727-11730
| Abstract »
| Full Text »
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- Tumor Necrosis Factor [IMAGE] Facilitates Nuclear Actions of Retinoic Acid to Regulate Expression of the Alkaline Phosphatase Gene in Preosteoblasts.
- S. S. Manji, H. Zhou, D. M. Findlay, T. J. Martin, and K. W. Ng (1995)
J. Biol. Chem.
270, 8958-8962
| Abstract »
| Full Text »
| PDF »
- Enhanced Cytokine Production and Collagen Synthesis of Gingival Fibroblasts from Patients with Denture Fibromatosis.
- K. Nakao, K. Yoneda, and T. Osaki (1995)
Journal of Dental Research
74, 1072-1078
| Abstract »
| PDF »
- Cellular Proliferation and Activation of NFkappaB Are Induced by Autocrine Production of Tumor Necrosis Factor alpha in the Human T Lymphoma Line HuT 78.
- M. A. O'Connell, R. Cleere, A. Long, and D. Kelleher (1995)
J. Biol. Chem.
270, 7399-7404
| Abstract »
| Full Text »
| PDF »
- Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.
- P De Togni, J Goellner, N. Ruddle, P. Streeter, A Fick, S Mariathasan, S. Smith, R Carlson, L. Shornick, J Strauss-Schoenberger, et al. (1994)
Science
264, 703-707
| Abstract »
| PDF »
- Liposomal Applications to Cancer Therapy.
- Y. Namba and N. Oku (1993)
Journal of Bioactive and Compatible Polymers
8, 158-177
| PDF »
- Tumor Necrosis Factor and Chemotherapeutic Agents: Potentiation of Cytotoxicity With Interferon Gamma.
- D. E. Dawson, M. Gapany, R. C. Burgess, P. V. Boesen, and D. B. Headley (1992)
Arch Otolaryngol Head Neck Surg
118, 1168-1171
| Abstract »
| PDF »
- Successful Combination Immunotherapy for the Generation In Vivo of Antitumor Activity With Anti-CD3, Interleukin 2, and Tumor Necrosis Factor {alpha}.
- S. C. Yang, K. D. Fry, E. A. Grimm, and J. A. Roth (1990)
Arch Surg
125, 220-225
| Abstract »
| PDF »
- Are the Catabolic Effects of Tumor Necrosis Factor Mediated by Glucocorticoids?.
- K. Mealy, J. J. B. van Lanschot, B. G. Robinson, J. Rounds, and D. W. Wilmore (1990)
Arch Surg
125, 42-48
| Abstract »
| PDF »
- Identification of monocyte chemotactic activity produced by malignant cells.
- D. Graves, Y. Jiang, M. Williamson, and A. Valente (1989)
Science
245, 1490-1493
| Abstract »
| PDF »
- Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism.
- G. Wong and D. Goeddel (1988)
Science
242, 941-944
| Abstract »
| PDF »
- Tumor Necrosis Factor in Middle Ear Effusions.
- D. Ophir, T. Hahn, A. Schattner, D. Wallach, and A. Aviel (1988)
Arch Otolaryngol Head Neck Surg
114, 1256-1258
| Abstract »
| PDF »
- Antiproliferative activity of a hybrid protein between interferon-gamma and tumor necrosis factor-beta.
- G. Feng, P. Gray, H. Shepard, and M. Taylor (1988)
Science
241, 1501-1503
| Abstract »
| PDF »
- Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.
- H Vlassara, M Brownlee, K. Manogue, C. Dinarello, and A Pasagian (1988)
Science
240, 1546-1548
| Abstract »
| PDF »
- Lymphotoxin is an important T cell-derived growth factor for human B cells.
- J. Kehrl, M Alvarez-Mon, G. Delsing, and A. Fauci (1987)
Science
238, 1144-1146
| Abstract »
| PDF »
- Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical.
- P. Sehgal, L. May, I Tamm, and J Vilcek (1987)
Science
235, 731-732
| PDF »
- Tumor necrosis factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells.
- A Yarden and A Kimchi (1986)
Science
234, 1419-1421
| Abstract »
| PDF »
- Lymphokines and Monokines in Anti-cancer Therapy.
- W. Fiers, P. Brouckaert, R. Devos, L. Fransen, G. Leroux-Roels, E. Remaut, P. Suffys, J. Tavernier, J. Van der Heyden, and F. Van Roy (1986)
Cold Spring Harb Symp Quant Biol
51, 587-595
| Abstract »
| PDF »
- Tumor Necrosis Factors: Gene Structure and Biological Activities.
- D.V. Goeddel, B.B. Aggarwal, P.W. Gray, D.W. Leung, G.E. Nedwin, M.A. Palladino, J.S. Patton, D. Pennica, H.M. Shepard, B.J. Sugarman, et al. (1986)
Cold Spring Harb Symp Quant Biol
51, 597-609
| Abstract »
| PDF »
- Tandem Arrangement of Genes Coding for Tumor Necrosis Factor (TNF-{alpha}) and Lymphotoxin (TNF-{beta}) in the Human Genome.
- S.A. Nedospasov, A.N. Shakhov, R.L. Turetskaya, V.A. Mett, M.M. Azizov, G.P. Georgiev, V.G. Korobko, V.N. Dobrynin, S.A. Filippov, N.S. Bystrov, et al. (1986)
Cold Spring Harb Symp Quant Biol
51, 611-624
| Abstract »
| PDF »
- Interferon gamma (IFNgamma ) and Tumor Necrosis Factor alpha Synergism in ME-180 Cervical Cancer Cell Apoptosis and Necrosis. IFNgamma INHIBITS CYTOPROTECTIVE NF-kappa B THROUGH STAT1/IRF-1 PATHWAYS.
- K. Suk, I. Chang, Y.-H. Kim, S. Kim, J. Y. Kim, H. Kim, and M.-S. Lee (2001)
J. Biol. Chem.
276, 13153-13159
| Abstract »
| Full Text »
| PDF »
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