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Science 15 November 1985:
Vol. 230. no. 4727, pp. 815 - 818
DOI: 10.1126/science.2414847
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Articles

Science, Vol 230, Issue 4727, 815-818
Copyright © 1985 by American Association for the Advancement of Science

articles

Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope

DE Arnot, JW Barnwell, JP Tam, V Nussenzweig, RS Nussenzweig, and V Enea

The gene encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium vivax has been cloned. The deduced sequence of the protein consists of 373 amino acids with a central region of 19 tandem repeats of the nonapeptide Asp-Arg-Ala-Asp/Ala-Gly-Gln-Pro-Ala-Gly. A synthetic 18-amino acid peptide containing two tandem repeats binds to a monoclonal antibody directed to the CS protein of Plasmodium vivax and inhibits the interaction of this antibody with the native protein in sporozoite extracts. The portions of the CS gene that do not contain repeats are closely related to the corresponding regions of the CS genes of two simian malarias, Plasmodium cynomolgi and Plasmodium knowlesi. In contrast, the homology between the CS genes of Plasmodium vivax and Plasmodium falciparum, another malaria parasite of humans, is very limited.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Partial Protection against Plasmodium vivax Blood-Stage Infection in Saimiri Monkeys by Immunization with a Recombinant C-Terminal Fragment of Merozoite Surface Protein 1 in Block Copolymer Adjuvant.
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Differential Susceptibilities of Anopheles albimanus and Anopheles pseudopunctipennis to Infections with Coindigenous Plasmodium vivax Variants VK210 and VK247 in Southern Mexico.
L. Gonzalez-Ceron, M. H. Rodriguez, J. C. Nettel, C. Villarreal, K. C. Kain, and J. E. Hernandez (1999)
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Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence.
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Cell-adhesive motif in region II of malarial circumsporozoite protein.
K. Rich, F. George 4th, J. Law, and W. Martin (1990)
Science 249, 1574-1577
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Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
R Rosenberg, R. Wirtz, D. Lanar, J Sattabongkot, T Hall, A. Waters, and C Prasittisuk (1989)
Science 245, 973-976
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Research toward malaria vaccines.
L. Miller, R. Howard, R Carter, M. Good, V Nussenzweig, and R. Nussenzweig (1986)
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