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Science 15 November 1985:
Vol. 230. no. 4727, pp. 777 - 783
DOI: 10.1126/science.2997918
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Articles

Science, Vol 230, Issue 4727, 777-783
Copyright © 1985 by American Association for the Advancement of Science

articles

Histocompatibility antigens on murine tumors

RS Goodenow, JM Vogel, and RL Linsk

Recent advances in tumor immunology suggest that the expression of the histocompatibility antigens, encoded by the major histocompatibility complex, is important in controlling the metastatic growth of certain murine tumors. The anomalous expression of histocompatibility antigens in many neoplasms appears to be associated with the ability of these cells to evade the immune system and progress to metastasis. This review examines some of the underlying molecular and immunobiological interactions that might determine the metastatic outcome of cellular transformation.


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