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Science 8 November 1985:
Vol. 230. no. 4726, pp. 681 - 683
DOI: 10.1126/science.2996146
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Articles

Science, Vol 230, Issue 4726, 681-683
Copyright © 1985 by American Association for the Advancement of Science

articles

Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist

T Wieloch

The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.


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