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Science 8 November 1985: Vol. 230. no. 4726, pp. 676 - 678 DOI: 10.1126/science.2996144
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Articles
Science, Vol 230, Issue 4726, 676-678
Copyright © 1985 by American Association for the Advancement of Science
Wounding and its role in RSV-mediated tumor formation
DS Dolberg,
R Hollingsworth,
M Hertle,
and
MJ Bissell
Tumors induced in chickens by Rous sarcoma virus remain localized at the site of injection even though the animals become viremic. Tumors have now been shown to be inducible at other sites if a wound is inflicted or if the tissue is injured by administration of tumor promoters. These findings indicate that local wounding plays a role in the spread of tumorigenicity of Rous sarcoma virus.
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