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Science 8 November 1985:
Vol. 230. no. 4726, pp. 672 - 674
DOI: 10.1126/science.3840278
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Articles

Science, Vol 230, Issue 4726, 672-674
Copyright © 1985 by American Association for the Advancement of Science

articles

Chromosomal locations of human tissue plasminogen activator and urokinase genes

B Rajput, SF Degen, E Reich, EK Waller, J Axelrod, RL Eddy, and TB Shows

A panel of human-mouse somatic cell hybrids and specific complementary DNA probes were used to map the human tissue plasminogen activator and urokinase genes to human chromosomes 8 and 10, respectively. This result is in contrast to a previous assignment of a plasminogen activator gene to chromosome 6. As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mos and c-myc, have also been mapped to chromosome 8.




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