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Science 8 November 1985:
Vol. 230. no. 4726, pp. 669 - 672
DOI: 10.1126/science.2413549
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Articles

Science, Vol 230, Issue 4726, 669-672
Copyright © 1985 by American Association for the Advancement of Science

articles

Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro

P Saiag, B Coulomb, C Lebreton, E Bell, and L Dubertret

A skin equivalent model has been used to fabricate tissues with psoriatic and normal cells. Psoriatic fibroblasts can induce hyperproliferative activity in normal keratinocytes. The psoriatic epidermis from lesions continues to proliferate at high rates for at least 15 days in this model, and normal fibroblasts are unable to suppress this hyperproliferation. The primary defect in psoriatic skin may reside in the dermal fibroblast.


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