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Science 8 November 1985:
Vol. 230. no. 4726, pp. 633 - 639
DOI: 10.1126/science.2996141
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Articles

Science, Vol 230, Issue 4726, 633-639
Copyright © 1985 by American Association for the Advancement of Science

articles

Structure of the human interleukin-2 receptor gene

WJ Leonard, JM Depper, M Kanehisa, M Kronke, NJ Peffer, PB Svetlik, M Sullivan, and WC Greene

The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site.


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