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Science 1 November 1985:
Vol. 230. no. 4725, pp. 570 - 573
DOI: 10.1126/science.2996140
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Articles

Science, Vol 230, Issue 4725, 570-573
Copyright © 1985 by American Association for the Advancement of Science

articles

Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation

IS Chen, AJ Cann, NP Shah, and RB Gaynor

The mechanism of cellular transformation by the human T-cell leukemia viruses (HTLV) is thought to involve a novel gene known as the x gene. This gene is essential for HTLV replication and acts by enhancing transcription from the HTLV long terminal repeat. The HTLV x gene product may also cause aberrant transcription of normal cellular genes, resulting in transformation of the infected cells. Although there is no evidence as yet for such a mechanism, it was shown that the HTLV-II x gene product can activate transcription from adenovirus E1A-dependent early promoters and therefore has the potential to activate cellular genes. It was also shown that the adenovirus and herpes pseudorabies immediate early proteins activate expression from the HTLV-I and HTLV-II long terminal repeats, though at lower levels than with the x gene product. These findings indicate possible common mechanisms of action for transcription-regulatory genes of distinct viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mouse Model for the Equilibration Interaction between the Host Immune System and Human T-Cell Leukemia Virus Type 1 Gene Expression.
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GLI-2 Modulates Retroviral Gene Expression.
M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
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Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-kappa B in Apoptosis-Resistant T-Cell Transfectants with Tax.
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Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome.
A. Tanimura, S. Dan, and M. Yoshida (1998)
J. Virol. 72, 3958-3964
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Regulation of HIV and HTLV gene expression..
H Varmus (1988)
Genes & Dev. 2, 1055-1062
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HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
W Wachsman, A. Cann, J. Williams, D. Slamon, L Souza, N. Shah, and I. Chen (1987)
Science 235, 674-677
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Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products.
R Hen, E Borrelli, and P Chambon (1985)
Science 230, 1391-1394
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