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Science 1 November 1985:
Vol. 230. no. 4725, pp. 561 - 563
DOI: 10.1126/science.2931802
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Articles

Science, Vol 230, Issue 4725, 561-563
Copyright © 1985 by American Association for the Advancement of Science

articles

Selective sparing of a class of striatal neurons in Huntington's disease

RJ Ferrante, NW Kowall, MF Beal, EP Richardson Jr, ED Bird, and JB Martin

A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in Huntington's disease. Biochemical assays confirmed a significant increase in the activity of this enzyme in both the caudate nucleus and putamen in postmortem brain tissue from patients with this disease. The resistance of these neurons suggests that the gene defect in Huntington's disease may be modifiable by the local biochemical environment. This finding may provide insight into the nature of the genetically programmed cell death that is a characteristic of the disease.


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