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Science 1 November 1985:
Vol. 230. no. 4725, pp. 553 - 556
DOI: 10.1126/science.3901257
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Articles

Science, Vol 230, Issue 4725, 553-556
Copyright © 1985 by American Association for the Advancement of Science

articles

A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites

D Camus and TJ Hadley

Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malaria parasite (Plasmodium falciparum). A 175-kilodalton (175K) antigen bound only to erythrocytes susceptible to invasion. The 175K antigen from the Camp or the FCR-3 strain also bound to merozoites. However, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invaded normally by merozoites of the homologous strain but were partially resistant to invasion by merozoites of the heterologous strain. The 175K antigen may be a receptor acting as a "bridge" between erythrocytes and merozoites.


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