Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 October 1985:
Vol. 230. no. 4723, pp. 330 - 332
DOI: 10.1126/science.4048937
Prev | Table of Contents

Articles

Science, Vol 230, Issue 4723, 330-332
Copyright © 1985 by American Association for the Advancement of Science

articles

Leukotrienes as mediators in tissue trauma

C Denzlinger, S Rapp, W Hagmann, and D Keppler

A significant increase in the production of cysteinyl leukotrienes was observed after mechanical or thermal trauma in the anesthesized rat. The amount of biliary N-acetyl-leukotriene E4, which represents a suitable indicator for blood plasma leukotrienes, was used as a measure of leukotriene generation. Cysteinyl leukotrienes were rapidly eliminated from blood plasma into bile where N-acetyl-leukotriene E4 was the major metabolite. Leukotrienes were at a much lower concentration in blood plasma than in bile and differed in the pattern of metabolites. The detected amounts of leukotrienes were sufficient to induce known phenomena associated with trauma, such as tissue edema and circulatory and respiratory dysfunction. Increased leukotriene generation appears to play an important role in the pathophysiology of tissue trauma.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhaled budesonide inhibits OVA-induced airway narrowing, inflammation, and cys-LT synthesis in BN rats.
L. Xu, R. Olivenstein, J. G. Martin, and W. S. Powell (2000)
J Appl Physiol 89, 1852-1858
   Abstract »    Full Text »    PDF »
gamma -Glutamyl Leukotrienase, a gamma -Glutamyl Transpeptidase Gene Family Member, Is Expressed Primarily in Spleen.
B. Z. Carter, Z.-Z. Shi, R. Barrios, and M. W. Lieberman (1998)
J. Biol. Chem. 273, 28277-28285
   Abstract »    Full Text »    PDF »
Endogenous Glutathione Conjugates: Occurrence and Biological Functions.
W. Wang and N. Ballatori (1998)
Pharmacol. Rev. 50, 335-356
   Abstract »    Full Text »    PDF »
Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis.
X. X. Yang, W. S. Powell, M. Hojo, and J. G. Martin (1997)
J Appl Physiol 82, 538-544
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)