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Science 18 October 1985:
Vol. 230. no. 4723, pp. 325 - 327
DOI: 10.1126/science.4048936
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Articles

Science, Vol 230, Issue 4723, 325-327
Copyright © 1985 by American Association for the Advancement of Science

articles

Induction of autoimmune thyroiditis in chickens by dietary iodine

N Bagchi, TR Brown, E Urdanivia, and RS Sundick

Clinical studies have suggested that excess dietary iodine promotes autoimmune thyroiditis; however, the lack of a suitable animal model has hampered investigation of the phenomenon. In this study, different amounts of potassium iodide were added to the diets of chicken strains known to be genetically susceptible to autoimmune thyroiditis. Administration of iodine during the first 10 weeks of life increased the incidence of the disease, as determined by histology and the measurement of autoantibodies to triiodothyronine, thyroxine, and thyroglobulin. Further support for the relation between iodine and autoimmune thyroiditis was provided by an experiment in which iodine-deficient regimens decreased the incidence of thyroid autoantibodies in a highly susceptible strain. These results suggest that excessive consumption of iodine in the United States may be responsible for the increased incidence of autoimmune thyroiditis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antithyroperoxidase and Antithyroglobulin Antibodies in a Five-Year Follow-Up Survey of Populations with Different Iodine Intakes.
Y. Li, D. Teng, Z. Shan, X. Teng, H. Guan, X. Yu, C. Fan, W. Chong, F. Yang, H. Dai, et al. (2008)
J. Clin. Endocrinol. Metab. 93, 1751-1757
   Abstract »    Full Text »    PDF »
Induction of Goitrous Hypothyroidism by Dietary Iodide in SJL Mice.
H. S. Li and G. Carayanniotis (2007)
Endocrinology 148, 2747-2752
   Abstract »    Full Text »    PDF »
Searching for the Autoimmune Thyroid Disease Susceptibility Genes: From Gene Mapping to Gene Function.
Y. Tomer and T. F. Davies (2003)
Endocr. Rev. 24, 694-717
   Abstract »    Full Text »    PDF »
Dual Roles for IFN-{gamma}, But Not for IL-4, in Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice.
S. Yu, G. C. Sharp, and H. Braley-Mullen (2002)
J. Immunol. 169, 3999-4007
   Abstract »    Full Text »    PDF »
Enhanced Iodination of Thyroglobulin Facilitates Processing and Presentation of a Cryptic Pathogenic Peptide.
Y. D. Dai, V. P. Rao, and G. Carayanniotis (2002)
J. Immunol. 168, 5907-5911
   Abstract »    Full Text »    PDF »
Postpartum Thyroiditis and Autoimmune Thyroiditis in Women of Childbearing Age: Recent Insights and Consequences for Antenatal and Postnatal Care.
A. F. Muller, H. A. Drexhage, and A. Berghout (2001)
Endocr. Rev. 22, 605-630
   Abstract »    Full Text »    PDF »
The Effects of Amiodarone on the Thyroid.
E. Martino, L. Bartalena, F. Bogazzi, and L. E. Braverman (2001)
Endocr. Rev. 22, 240-254
   Abstract »    Full Text »
Amiodarone-Induced Thyrotoxicosis.
G. H. Daniels (2001)
J. Clin. Endocrinol. Metab. 86, 3-8
   Full Text »
Enhanced Susceptibility to Amiodarone-Induced Hypothyroidism in Patients With Thyroid Autoimmune Disease.
E. Martino, F. Aghini-Lombardi, L. Bartalena, L. Grasso, A. Loviselli, F. Velluzzi, A. Pinchera, and L. E. Braverman (1994)
Arch Intern Med 154, 2722-2726
   Abstract »    PDF »


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