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Science 18 October 1985:
Vol. 230. no. 4723, pp. 319 - 322
DOI: 10.1126/science.2996131
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Articles

Science, Vol 230, Issue 4723, 319-322
Copyright © 1985 by American Association for the Advancement of Science

articles

Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma

CE Rogler, M Sherman, CY Su, DA Shafritz, J Summers, TB Shows, A Henderson, and M Kew

Hepatitis B virus (HBV), a virus with known carcinogenic potential, integrates into cellular DNA during long-term persistent infection in man. Hepatocellular carcinomas isolated from viral carriers often contain clonally propagated viral DNA integrations. As small chromosomal deletions are associated with several types of carcinomas, the occurrence of chromosomal deletions in association with HBV integration in hepatocellular carcinoma was studied. HBV integration was accompanied by a deletion of at least 13.5 kilobases of cellular sequences in a human hepatocellular carcinoma. The viral DNA integration and deletion of cellular sequences occurred on the short arm of chromosome 11 at location 11p13-11p14. The cellular sequences that were deleted at the site of HBV integration were lost from the tumor cells, leaving only a single copy of the remaining cellular allele.


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The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma..
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Mapping of Human Chromosome 11: Organization of Genes within the Wilms' Tumor Region of the Chromosome.
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The Chromosome 11 Gene Map: Genes for Growth and Development, Wilms' Tumor Deletions, and Cancer Chromosome Breakpoints.
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