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Science 4 October 1985:
Vol. 230. no. 4721, pp. 87 - 88
DOI: 10.1126/science.2994226
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Articles

Science, Vol 230, Issue 4721, 87-88
Copyright © 1985 by American Association for the Advancement of Science

articles

Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid

TF O'Brien, MP Pla, KH Mayer, H Kishi, E Gilleece, M Syvanen, and JD Hopkins

Bacteria of different genera isolated at nine medical centers in different parts of the United States and at one center in Venezuela during the first decade of gentamicin usage carried the gentamicin resistance gene 2"-aminoglycoside nucleotidyltransferase on the same transferable plasmid. Such widespread dissemination of a newly observed resistance gene on one plasmid suggests that a new resistance gene may emerge once on a single plasmid, which then carries it to other centers and other plasmids. The resistance gene might, therefore, be contained if detected early.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mercury Resistance Determinants Related to Tn21, Tn1696, and Tn5053 in Enterobacteria from the Preantibiotic Era.
A. M. M. Essa, D. J. Julian, S. P. Kidd, N. L. Brown, and J. L. Hobman (2003)
Antimicrob. Agents Chemother. 47, 1115-1119
   Abstract »    Full Text »    PDF »
Isolation of Broad-Host-Range Replicons from Marine Sediment Bacteria.
P. A. Sobecky, T. J. Mincer, M. C. Chang, A. Toukdarian, and D. R. Helinski (1998)
Appl. Envir. Microbiol. 64, 2822-2830
   Abstract »    Full Text »
Rhizobium gone native: Unexpected plasmid stability of indigenous Rhizobium leguminosarum.
J. J. Wernegreen, E. E. Harding, and M. A. Riley (1997)
PNAS 94, 5483-5488
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)