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Science 4 October 1985:
Vol. 230. no. 4721, pp. 82 - 84
DOI: 10.1126/science.4035359
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Articles

Science, Vol 230, Issue 4721, 82-84
Copyright © 1985 by American Association for the Advancement of Science

articles

Z-DNA forms without an alternating purine-pyrimidine sequence in solution

J Feigon, AH Wang, GA van der Marel, JH van Boom, and A Rich

Nuclear magnetic resonance spectra (proton and phosphorus-31) and ultraviolet absorption spectra of the DNA decamer d(br5CGbr5CGATbr5CGbr5CG), in which the central two adenine-thymine base pairs are out of order with the rest of the purine-pyrimidine alternation sequence, indicate that under appropriate solvent conditions (high salt and methanol) the molecule undergoes a structural transition from a right-handed B-DNA conformation to a left-handed Z-DNA conformation. Measurements of the two-dimensional nuclear Overhauser effect on the decamer indicate that all of the guanines as well as the two equivalent thymines adopt the syn conformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Non-B DNA Conformations Formed by Long Repeating Tracts of Myotonic Dystrophy Type 1, Myotonic Dystrophy Type 2, and Friedreich's Ataxia Genes, Not the Sequences per se, Promote Mutagenesis in Flanking Regions.
M. Wojciechowska, M. Napierala, J. E. Larson, and R. D. Wells (2006)
J. Biol. Chem. 281, 24531-24543
   Abstract »    Full Text »    PDF »
Z-DNA-forming sequences generate large-scale deletions in mammalian cells.
G. Wang, L. A. Christensen, and K. M. Vasquez (2006)
PNAS 103, 2677-2682
   Abstract »    Full Text »    PDF »
Unusual DNA duplex and hairpin motifs.
S.-H. Chou, K.-H. Chin, and A. H.-J. Wang (2003)
Nucleic Acids Res. 31, 2461-2474
   Abstract »    Full Text »    PDF »
Z-DNA: still searching for a function.
J. Marx (1985)
Science 230, 794-796
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)