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Science 4 October 1985:
Vol. 230. no. 4721, pp. 76 - 78
DOI: 10.1126/science.3929385
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Articles

Science, Vol 230, Issue 4721, 76-78
Copyright © 1985 by American Association for the Advancement of Science

articles

Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice

G Furstenberger, V Kinzel, M Schwarz, and F Marks

Alterations in NMRI mouse skin induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in "stage I of tumor promotion" are slowly reversible, and this reversibility has a half-time of 10 to 12 weeks. The tumor response observed in the course of an initiation-promotion experiment in vivo is independent of whether stage I of promotion occurs before or after initiation. Since the time interval between treatment with the promoter, and subsequent initiation can be extended up to at least 6 weeks, an enhancement of initiation because of promoter-induced cellular DNA synthesis seems to be unlikely. This result may be inconsistent with the two-stage model of tumor promotion because it indicates that in skin the existence of initiated cells is not required for the induction of cellular alterations that are essential for the stage of skin tumorigenesis called stage I of promotion.


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Carcinogenesis 22, 1903-1930
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The Role of Free Radicals in Tumor Promotion: Oxy Radical Production by Murine Peritoneal Macrophages In Vivo in Response to Tumor Promoters.
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International Journal of Toxicology 8, 253-258
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