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Science 4 October 1985:
Vol. 230. no. 4721, pp. 71 - 73
DOI: 10.1126/science.2412295
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Articles

Science, Vol 230, Issue 4721, 71-73
Copyright © 1985 by American Association for the Advancement of Science

articles

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III

NL Letvin, MD Daniel, PK Sehgal, RC Desrosiers, RD Hunt, LM Waldron, JJ MacKey, DK Schmidt, LV Chalifoux, and NW King

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.


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AIDS as a Zoonosis: Scientific and Public Health Implications.
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Specific passage of simian immunodeficiency virus fromend-stage disease results in accelerated progression to AIDS in rhesus macaques.
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Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication.
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J. Virol. 73, 5466-5472
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Simian Immunodeficiency Virus Disease Course Is Predicted by the Extent of Virus Replication during Primary Infection.
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J. Virol. 73, 4829-4839
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J. Virol. 73, 4508-4512
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Science 241, 426-432
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Science 241, 199-201
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JAMA 256, 2365-2371
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Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus.
M. Power, P. Marx, M. Bryant, M. Gardner, P. Barr, and P. Luciw (1986)
Science 231, 1567-1572
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Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys.
P. Kanki, J Alroy, and M Essex (1985)
Science 230, 951-954
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Science. ISSN 0036-8075 (print), 1095-9203 (online)