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Science 27 September 1985:
Vol. 229. no. 4720, pp. 1407 - 1408
DOI: 10.1126/science.4035357
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Articles

Science, Vol 229, Issue 4720, 1407-1408
Copyright © 1985 by American Association for the Advancement of Science

articles

Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients

P Heinz-Erian, RD Dey, M Flux, and SI Said

The innervation of acini and ducts of eccrine sweat glands by immunoreactive, vasoactive intestinal peptide-containing nerve fibers was sharply reduced in seven patients with cystic fibrosis compared to eight normal subjects. The decrease in innervation by this neuropeptide, which has been shown to promote blood flow and the movement of water and chloride across epithelial surfaces in other systems, may be a basic mechanism for the decreased water content and relative impermeability of the epithelium to chloride and other ions that characterize cystic fibrosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis.
D. L. Kellogg Jr., G. J. Hodges, C. R. Orozco, T. M. Phillips, J. L. Zhao, and J. M. Johnson (2007)
J Appl Physiol 103, 963-968
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Preserved reflex cutaneous vasodilation in cystic fibrosis does not include an enhanced nitric oxide-dependent mechanism.
B. W. Wilkins, E. A. Martin, S. K. Roberts, and M. J. Joyner (2007)
J Appl Physiol 102, 2301-2306
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Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
   Abstract »    Full Text »    PDF »
In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges.
D. L. Kellogg Jr (2006)
J Appl Physiol 100, 1709-1718
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Submucosal Glands and Airway Defense.
J. J. Wine and N. S. Joo (2004)
Proceedings of the ATS 1, 47-53
   Abstract »    Full Text »    PDF »
Evidence for a Role for Vasoactive Intestinal Peptide in Active Vasodilatation in the Cutaneous Vasculature of Humans.
L. A. T Bennett, J. M Johnson, D. P Stephens, A. R Saad, and D. L Kellogg Jr (2003)
J. Physiol. 552, 223-232
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Stabilization of Vasoactive Intestinal Peptide by Lipids.
G. Gololobov, Y. Noda, S. Sherman, I. Rubinstein, J. Baranowska-Kortylewicz, and S. Paul (1998)
J. Pharmacol. Exp. Ther. 285, 753-758
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Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis.
R. Lucchini, F Facchini, G Turato, M Saetta, G Caramori, A Ciaccia, P Maestrelli, D. Springall, J. Polak, L Fabbri, et al. (1997)
Am. J. Respir. Crit. Care Med. 156, 1963-1968
   Abstract »    Full Text »
Uranium Enrichment's $7-Billion Uncertainty: The federal government's enrichment program is getting back into the black, but disputes loom over the amount owed to the Treasury and the future of a major R&D program.
C. NORMAN (1986)
Science 232, 312-313
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