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Science 27 September 1985:
Vol. 229. no. 4720, pp. 1390 - 1393
DOI: 10.1126/science.3929382

Articles

Science, Vol 229, Issue 4720, 1390-1393
Copyright © 1985 by American Association for the Advancement of Science


articles

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining

Y Tsujimoto, J Gorham, J Cossman, E Jaffe, and CM Croce

In this study, the joining sequences between chromosomes 14 and 18 on the 14q+ chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18) chromosome translocation were analyzed. In each case, the involved segment of chromosome 18 has recombined with the immunoglobulin heavy-chain joining segment (JH) on chromosome 14. The sites of the recombination on chromosome 14 are located close to the 5' end of the involved JH segment, where the diversity (D) regions are rearranged with the JH segments in the production of active heavy-chain genes. As extraneous nucleotides (N regions) were observed at joining sites and specific signal-like sequences were detected on chromosome 18 in close proximity to the breakpoints, it is concluded that the t(14;18) chromosome translocation is the result of a mistake during the process of VDJ joining at the pre-B-cell stage of differentiation. The putative recombinase joins separated DNA segments on two different chromosomes instead of joining separated segments on the same chromosome, causing a t(14;18) chromosome translocation in the involved B cells.


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The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans.
H.R. Horvitz, S. Shaham, and M.O. Hengartner (1994)
Cold Spring Harb Symp Quant Biol 59, 377-385
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Bcl-2 Gene Family and the Regulation of Programmed Cell Death.
X.-M. Yin, Z.N. Oltvai, D.J. Veis-Novack, G.P. Linette, and S.J. Korsmeyer (1994)
Cold Spring Harb Symp Quant Biol 59, 387-393
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Chromosome aberrations and cancer.
E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
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Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.
M Hatano, C. Roberts, M Minden, W. Crist, and S. Korsmeyer (1991)
Science 253, 79-82
   Abstract »    PDF »
Detection of minimal residual cells carrying the t(14;18) by DNA sequence amplification.
M. Lee, K. Chang, F Cabanillas, E. Freireich, J. Trujillo, and S. Stass (1987)
Science 237, 175-178
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Programmed gene rearrangements altering gene expression.
P Borst and D. Greaves (1987)
Science 235, 658-667
   Abstract »    PDF »
A common mechanism of chromosomal translocation in T- and B-cell neoplasia.
L. Finger, R. Harvey, R. Moore, L. Showe, and C. Croce (1986)
Science 234, 982-985
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Differentiation-linked leukemogenesis in lymphocytes.
M. Greaves (1986)
Science 234, 697-704
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Molecular Genetics of Human B- and T-cell Neoplasia.
C.M. Croce, J. Erikson, F.G. Haluska, L.R. Finger, L.C. Showe, and Y. Tsujimoto (1986)
Cold Spring Harb Symp Quant Biol 51, 891-898
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