Related Content
Search Google Scholar for:
|
|
Science 20 September 1985:
Vol. 229. no. 4719, pp. 1274 - 1277
DOI: 10.1126/science.3839937
|
|
Articles
Science, Vol 229, Issue 4719, 1274-1277
Copyright © 1985 by American Association for the Advancement of Science
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase
BA Harris,
JD Robishaw,
SM Mumby,
and
AG Gilman
A complementary DNA clone encoding the alpha subunit of the adenylate cyclase stimulatory G protein (Gs) was isolated and identified. A bovine brain complementary DNA library was screened with an oligonucleotide probe derived from amino acid sequence common to known G proteins. The only clone that was obtained with this probe has a complementary DNA insert of approximately 1670 base pairs. An antibody to a peptide synthesized according to deduced amino acid sequence reacts specifically with the alpha subunit of Gs. In addition, RNA that hybridizes with probes made from the clone is detected in wild-type S49 cells; however, cyc- S49 cells, which are deficient in Gs alpha activity, are devoid of this messenger RNA.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Genetic Analysis of the Drosophila Gs{{alpha}} Gene.
- W. J. Wolfgang, A. Hoskote, I. J. H. Roberts, S. Jackson, and M. Forte (2001)
Genetics
158, 1189-1201
| Abstract »
| Full Text »
| PDF »
- A Surface-Exposed Region of Gsalpha in Which Substitutions Decrease Receptor-Mediated Activation and Increase Receptor Affinity.
- G. Grishina and C. H. Berlot (2000)
Mol. Pharmacol.
57, 1081-1092
| Abstract »
| Full Text »
- Mutations at the Domain Interface of Gsalpha Impair Receptor-mediated Activation by Altering Receptor and Guanine Nucleotide Binding.
- G. Grishina and C. H. Berlot (1998)
J. Biol. Chem.
273, 15053-15060
| Abstract »
| Full Text »
| PDF »
- Receptor-Mediated Activation of Gsalpha : Evidence for Intramolecular Signal Transduction.
- S. R. Marsh, G. Grishina, P. T. Wilson, and C. H. Berlot (1998)
Mol. Pharmacol.
53, 981-990
| Abstract »
| Full Text »
- Reproductive Dysfunction in Women with Albright's Hereditary Osteodystrophy.
- A. B. Namnoum, G. R. Merriam, A. M. Moses, and M. A. Levine (1998)
J. Clin. Endocrinol. Metab.
83, 824-829
| Abstract »
| Full Text »
- The Stability of the Agonist beta 2-Adrenergic Receptor-Gs Complex: Evidence for Agonist-Specific States.
- A. M. Krumins and R. Barber (1997)
Mol. Pharmacol.
52, 144-154
| Abstract »
| Full Text »
- Olfactory Dysfunction in Type I Pseudohypoparathyroidism: Dissociation from Gs{alpha} Protein Deficiency.
- R. L. Doty, A. D. Fernandez, M. A. Levine, A. Moses, and D. A. McKeown (1997)
J. Clin. Endocrinol. Metab.
82, 247-250
| Abstract »
| Full Text »
| PDF »
- Evidence That Phospholipase delta 1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling.
- J.-F. Feng, S. G. Rhee, and M.-J. Im (1996)
J. Biol. Chem.
271, 16451-16454
| Abstract »
| Full Text »
| PDF »
- Separate GTP binding and GTPase activating domains of a G alpha subunit.
- D. Markby, R Onrust, and H. Bourne (1993)
Science
262, 1895-1901
| Abstract »
| PDF »
- Golf: an olfactory neuron specific-G protein involved in odorant signal transduction.
- D. Jones and R. Reed (1989)
Science
244, 790-795
| Abstract »
| PDF »
- Structures of the Genes Coding for G-protein a Subunits from Mammalian and Yeast Cells.
- Y. Kaziro, H. Itoh, T. Kozasa, R. Toyama, T. Tsukamoto, M. Matsuoka, M. Nakafuku, T. Obara, T. Takagi, and R. Hernandez (1988)
Cold Spring Harb Symp Quant Biol
53, 209-220
| Abstract »
| PDF »
- Chimeric Melatonin mt1 and Melatonin-related Receptors. IDENTIFICATION OF DOMAINS AND RESIDUES PARTICIPATING IN LIGAND BINDING AND RECEPTOR ACTIVATION OF THE MELATONIN mt1 RECEPTOR.
- S. Conway, J. E. Drew, E. S. Mowat, P. Barrett, P. Delagrange, and P. J. Morgan (2000)
J. Biol. Chem.
275, 20602-20609
| Abstract »
| Full Text »
| PDF »
|
|
