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Science 20 September 1985:
Vol. 229. no. 4719, pp. 1268 - 1271
DOI: 10.1126/science.4035355
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Articles

Science, Vol 229, Issue 4719, 1268-1271
Copyright © 1985 by American Association for the Advancement of Science

articles

Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets

SK McConnell

Cells from the cerebral proliferative zones of newborn ferrets were labeled with tritiated thymidine and a fluorescent dye and were transplanted as a single-cell suspension into the occipital region of newborn ferrets. The transplanted cells became thoroughly integrated into the host environment: many cells migrated through the intermediate zone and into the cortical plate, where they developed as pyramidal neurons. Other transplanted cells came to resemble glial cells. After 1 to 2 months most transplanted neurons had taken up residence in layer 2 + 3, the normal destination of neurons generated on postnatal days 1 and 2. Thus the sequence of morphological differentiation and the eventual laminar position of the isochronically transplanted neurons closely paralleled that of their normal host counterparts.


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