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Science 20 September 1985:
Vol. 229. no. 4719, pp. 1265 - 1268
DOI: 10.1126/science.4035354
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Articles

Science, Vol 229, Issue 4719, 1265-1268
Copyright © 1985 by American Association for the Advancement of Science

articles

Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines

T Curran and JI Morgan

Alterations in proto-oncogene expression after stimulation of rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) have been investigated. A specific stimulation of c-fos messenger RNA and protein was detected 30 minutes after treatment. This induction was enhanced more than 100-fold in the presence of peripherally active benzodiazepines. The effect was specific as very little change was observed in the levels of c-rasHa, c-rasKi, c-myc, and N-myc messenger RNA's. Under the conditions used here, NGF treatment ultimately results in neurite outgrowth, with a reduction or cessation of cell division. Thus, stimulation of the c-fos gene in this system appeared to be associated with differentiation and not with cellular proliferation. The effect of benzodiazepines was stereospecific and represents a novel action of these compounds at the level of gene expression.


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