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Science 20 September 1985:
Vol. 229. no. 4719, pp. 1236 - 1242
DOI: 10.1126/science.3898362
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Articles

Science, Vol 229, Issue 4719, 1236-1242
Copyright © 1985 by American Association for the Advancement of Science

articles

Spatially regulated expression of homeotic genes in Drosophila

K Harding, C Wedeen, W McGinnis, and M Levine

The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.


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A chemically synthesized Antennapedia homeo domain binds to a specific DNA sequence.
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Cross-regulatory interactions among pair-rule genes in Drosophila.
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M. Levine, K. Harding, C. Wedeen, H. Doyle, T. Hoey, and H. Radomska (1985)
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Embryonic Pattern in Drosophila: The Spatial Distribution and Sequence-specific DNA Binding of engrailed Protein.
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