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Science 13 September 1985:
Vol. 229. no. 4718, pp. 1099 - 1101
DOI: 10.1126/science.4035350
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Articles

Science, Vol 229, Issue 4718, 1099-1101
Copyright © 1985 by American Association for the Advancement of Science

articles

Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth

AJ Mukkada, JC Meade, TA Glaser, and PF Bonventre

Amastigotes (tissue forms) of Leishmania donovani isolated from infected hamster spleens carried out several physiological activities (respiration, catabolism of energy substrates, and incorporation of precursors into macromolecules) optimally at pH 4.0 to 5.5. All metabolic activities that were examined decreased sharply above the optimal pH. Promastigotes (culture forms), on the other hand, carried out the same metabolic activities optimally at or near neutral pH. This adaptation to an acid environment may account in part for the unusual ability of amastigotes to survive and multiply within the acidic environment of the phagolysosomes in vivo.


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