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Science 13 September 1985:
Vol. 229. no. 4718, pp. 1094 - 1097
DOI: 10.1126/science.2994212
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Articles

Science, Vol 229, Issue 4718, 1094-1097
Copyright © 1985 by American Association for the Advancement of Science

articles

Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide

SG Amara, JL Arriza, SE Leff, LW Swanson, RM Evans, and MG Rosenfeld

As a consequence of alternative RNA processing events, a single rat gene can generate messenger RNA's (mRNA's) encoding either calcitonin or a neuropeptide referred to as alpha-type calcitonin gene-related peptide (alpha-CGRP). An mRNA product of a related gene has been identified in rat brain and thyroid encoding the protein precursor of a peptide differing from alpha-CGRP by only a single amino acid. The RNA encoding this peptide, which is referred to as beta-CGRP, appears to be the only mature transcript of the beta-CGRP gene. Hybridization histochemistry reveals a similar distribution of alpha- and beta-CGRP mRNA's, but their relative levels of expression vary in different cranial nerve nuclei. Thus beta-CGRP is a new member of a family of related genes with potential functions in regulating the transduction of sensory and motor information.


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