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Science 13 September 1985:
Vol. 229. no. 4718, pp. 1090 - 1093
DOI: 10.1126/science.2412292
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Articles

Science, Vol 229, Issue 4718, 1090-1093
Copyright © 1985 by American Association for the Advancement of Science

articles

Antigenic variation and resistance to neutralization in poliovirus type 1

DC Diamond, BA Jameson, J Bonin, M Kohara, S Abe, H Itoh, T Komatsu, M Arita, S Kuge, A Nomoto, and al. et

Mutations have been identified in variants of poliovirus, type 1 (Mahoney) on the basis of their resistance to neutralization by individual monoclonal antibodies. The phenotypes of these variants were defined in terms of antibody binding; the pattern of epitopes expressed or able to be exploited for neutralization were complex. Single amino acid changes can have distant (in terms of linear sequence) and generalized effects on the antigenic structure of poliovirus and similarly constituted virions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity.
M. Arita, T. Wakita, and H. Shimizu (2008)
J. Gen. Virol. 89, 2518-2530
   Abstract »    Full Text »    PDF »
Evolution of wild-type 1 poliovirus in two healthy siblings excreting the virus over a period of 6 months.
T. Hovi, N. Lindholm, C. Savolainen, M. Stenvik, and C. Burns (2004)
J. Gen. Virol. 85, 369-377
   Abstract »    Full Text »    PDF »
Complete Genomic Sequencing Shows that Polioviruses and Members of Human Enterovirus Species C Are Closely Related in the Noncapsid Coding Region.
B. Brown, M. S. Oberste, K. Maher, and M. A. Pallansch (2003)
J. Virol. 77, 8973-8984
   Abstract »    Full Text »    PDF »
Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.
Y. Verlinden, A. Cuconati, E. Wimmer, and B. Rombaut (2000)
J. Gen. Virol. 81, 2751-2754
   Abstract »    Full Text »
Three-dimensional structure of poliovirus at 2.9 A resolution.
J. Hogle, M Chow, and D. Filman (1985)
Science 229, 1358-1365
   Abstract »    PDF »


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