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Science 13 September 1985:
Vol. 229. no. 4718, pp. 1051 - 1057
DOI: 10.1126/science.4035344
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Articles
Science, Vol 229, Issue 4718, 1051-1057
Copyright © 1985 by American Association for the Advancement of Science
Defining lipid transport pathways in animal cells
RE Pagano
and
RG Sleight
A new technique for studying the metabolism and intracellular transport of lipid molecules in living cells based on the use of fluorescent lipid analogs is described. The cellular processing of various intermediates (phosphatidic acid and ceramide) and end products (phosphatidylcholine and phosphatidylethanolamine) in lipid biosynthesis is reviewed and a working model for compartmentalization during lipid biosynthesis is presented.
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