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Science 6 September 1985:
Vol. 229. no. 4717, pp. 989 - 991
DOI: 10.1126/science.2992093
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Articles
Science, Vol 229, Issue 4717, 989-991
Copyright © 1985 by American Association for the Advancement of Science
Gonadotropin-releasing hormone binding sites in human breast carcinoma
KA Eidne,
CA Flanagan,
and
RP Millar
Gonadotropin-releasing hormone analogs can cause regression of hormone-dependent breast carcinomas. These effects are thought to be mediated through the inhibition of gonadotropic and steroid hormones. These analogs may also act directly on the tumor because they are effective in treating breast cancer in some postmenopausal women. The presence of specific binding sites for gonadotropin-releasing hormone was demonstrated in human breast carcinomas by means of a novel approach of ligand immunoblotting. The results indicate a possible mechanism by which the peptide has direct effects on this tissue. These binding proteins were not detectable in non-neoplastic breast tissue.
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