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Science 6 September 1985:
Vol. 229. no. 4717, pp. 974 - 976
DOI: 10.1126/science.2992089

Articles

Science, Vol 229, Issue 4717, 974-976
Copyright © 1985 by American Association for the Advancement of Science


articles

Amplification of a novel v-erbB-related gene in a human mammary carcinoma

CR King, MH Kraus, and SA Aaronson

The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to v-erbB but amplified in a manner that appeared to distinguish it from the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma.


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Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression.
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J. Exp. Med. 193, 521-530
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Segment-Specific c-ErbB2 Expression in Human Autosomal Recessive Polycystic Kidney Disease.
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Clin. Cancer Res. 6, 4217-4225
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Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk.
D. Xie, X.-O. Shu, Z. Deng, W.-Q. Wen, K. E. Creek, Q. Dai, Y.-T. Gao, F. Jin, and W. Zheng (2000)
J Natl Cancer Inst 92, 412-417
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Characterization of a Repressor Element and a Juxtaposed Tissue-restricted Activator Element Located on the Distal neu Gene Promoter.
T.-C. Suen and P. E. Goss (2000)
J. Biol. Chem. 275, 6600-6607
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Pharmacokinetics and Antitumor Activity of a Bivalent Disulfide-stabilized Fv Immunotoxin with Improved Antigen Binding to erbB2.
T. K. Bera, J. Viner, E. Brinkmann, and I. Pastan (1999)
Cancer Res. 59, 4018-4022
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Relationship between Protease Activity and neu Oncogene Expression in Patients with Oral Leukoplakia Treated with the Bowman Birk Inhibitor.
X. S. Wan, F. L. Meyskens Jr., W. B. Armstrong, T. H. Taylor, and A. R. Kennedy (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 601-608
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Serum sErbB1 and Epidermal Growth Factor Levels As Tumor Biomarkers in Women with Stage III or IV Epithelial Ovarian Cancer.
A. T. Baron, J. M. Lafky, C. H. Boardman, S. Balasubramaniam, V. J. Suman, K. C. Podratz, and N. J. Maihle (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 129-137
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Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo. IMPLICATIONS FOR HUMAN BREAST CANCER.
J. A. Engelman, R. J. Lee, A. Karnezis, D. J. Bearss, M. Webster, P. Siegel, W. J. Muller, J. J. Windle, R. G. Pestell, and M. P. Lisanti (1998)
J. Biol. Chem. 273, 20448-20455
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Expression of Q227L-Galpha s in MCF-7 human breast cancer cells inhibits tumorigenesis.
J. Chen, J. A. Bander, T. A. Santore, Y. Chen, P. T. Ram, M. J. Smit, and R. Iyengar (1998)
PNAS 95, 2648-2652
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Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes. I. ACTIVATION OF PROTEIN KINASE C STIMULATES TYROSINE PHOSPHORYLATION AND ACTIVATION OF ErbB2 AND ErbB3.
R. Emkey and C. R. Kahn (1997)
J. Biol. Chem. 272, 31172-31181
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The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells.
B. D. Cohen, P. A. Kiener, J. M. Green, L. Foy, H. P. Fell, and K. Zhang (1996)
J. Biol. Chem. 271, 30897-30903
   Abstract »    Full Text »    PDF »
c-erbB-2/p185-Directed Therapy in Human Lung Adenocarcinoma.
J. M. Snider, L. J. Bushnell, L. C. Chen, and L. A. Lanza (1996)
Ann. Thorac. Surg. 62, 1454-1459
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Induction of Acetylcholine Receptor Gene Expression by ARIA Requires Activation of Mitogen-activated Protein Kinase.
J. Si, Z. Luo, and L. Mei (1996)
J. Biol. Chem. 271, 19752-19759
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Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kappaB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation.
C. K. Galang, J. J. García-Ramírez, P. A. Solski, J. K. Westwick, C. J. Der, N. N. Neznanov, R. G. Oshima, and C. A. Hauser (1996)
J. Biol. Chem. 271, 7992-7998
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A 50 kDa protein present in conditioned medium of COLO-16 cells stimulates cell spreading and motility, and activates tyrosine phosphorylation of Neu/HER-2, in human SK-BR-3 mammary cancer cells.
V De Corte, C De Potter, D Vandenberghe, N Van Laerebeke, M Azam, H Roels, M Mareel, and J Vandekerckhove (1994)
J. Cell Sci. 107, 405-416
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Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice..
C T Guy, S K Muthuswamy, R D Cardiff, P Soriano, and W J Muller (1994)
Genes & Dev. 8, 23-32
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Identification of Heregulin, a Specific Activator of p185erbB2.
W. E. Holmes, M. X. Sliwkowski, R. W. Akita, W. J. Henzel, J. Lee, J. W. Park, D. Yansura, N. Abadi, H. Raab, G. D. Lewis, et al. (1992)
Science 256, 1205-1210
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Growth factors and cancer.
S. Aaronson (1991)
Science 254, 1146-1153
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Oncogene Amplification in Squamous Cell Carcinoma of the Head and Neck.
W. D. Merritt, M. C. Weissler, B. F. Turk, and T. M. Gilmer (1990)
Arch Otolaryngol Head Neck Surg 116, 1394-1398
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Advances in Diagnosis and Detection of Oral Diseases.
B.J. Baum, C.J. Burstone, R. Dubner, P. Goldhaber, M.J. Levine, W.J. Loesche, and V. Terranova (1989)
Advances in Dental Research 3, 7-13
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Amplification of c-erbB-2 and aggressive human breast tumors?.
D. Slamon and G. Clark (1988)
Science 240, 1795-1798
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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.
P. Di Fiore, J. Pierce, M. Kraus, O Segatto, C. King, and S. Aaronson (1987)
Science 237, 178-182
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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
D. Slamon, G. Clark, S. Wong, W. Levin, A Ullrich, and W. McGuire (1987)
Science 235, 177-182
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A novel human gene closely related to the abl proto-oncogene.
G. Kruh, C. King, M. Kraus, N. Popescu, S. Amsbaugh, W. McBride, and S. Aaronson (1986)
Science 234, 1545-1548
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The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.
T Akiyama, C Sudo, H Ogawara, K Toyoshima, and T Yamamoto (1986)
Science 232, 1644-1646
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The c-erbB-2 Gene Encodes a Receptor-like Protein with Tyrosine Kinase Activity.
K. Toyoshima, K. Semba, T. Akiyama, S. Ikawa, and T. Yamamoto (1986)
Cold Spring Harb Symp Quant Biol 51, 977-982
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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
L Coussens, T. Yang-Feng, Y. Liao, E Chen, A Gray, J McGrath, P. Seeburg, T. Libermann, J Schlessinger, U Francke, et al. (1985)
Science 230, 1132-1139
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c-Cbl Is a Suppressor of the Neu Oncogene.
G. Levkowitz, S. Oved, L. N. Klapper, D. Harari, S. Lavi, M. Sela, and Y. Yarden (2000)
J. Biol. Chem. 275, 35532-35539
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