Science 30 August 1985: Vol. 229. no. 4716, pp. 869 - 871 DOI: 10.1126/science.3895437

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Articles

Crucial Role of TNF Receptors 1 and 2 in the Control of Polymicrobial Sepsis.

T. Secher, V. Vasseur, D. M. Poisson, J. A. Mitchell, F. Q. Cunha, J. C. Alves-Filho, and B. Ryffel (2009)
J. Immunol. 182, 7855-7864
 |  Abstract »  |  Full Text »  |  PDF »

TLRs and innate immunity.

B. A. Beutler (2009)
Blood 113, 1399-1407
 |  Abstract »  |  Full Text »  |  PDF »

Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.

R. E. Yura, S. G. Bradley, G. Ramesh, W. B. Reeves, and J. S. Bond (2009)
Am J Physiol Renal Physiol 296, F135-F144
 |  Abstract »  |  Full Text »  |  PDF »

Detrimental Role of CC Chemokine Receptor 4 in Murine Polymicrobial Sepsis.

T. Traeger, W. Kessler, V. Assfalg, K. Cziupka, P. Koerner, C. Dassow, K. Breitbach, M. Mikulcak, I. Steinmetz, K. Pfeffer, et al. (2008)
Infect. Immun. 76, 5285-5293
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages.

Y.-G. Kim, J.-H. Park, S. Daignault, K. Fukase, and G. Nunez (2008)
J. Immunol. 181, 4340-4346
 |  Abstract »  |  Full Text »  |  PDF »

The Anti-inflammatory Effects of Curcuma longa and Berberis aristata in Endotoxin-Induced Uveitis in Rabbits.

S. K. Gupta, R. Agarwal, S. Srivastava, P. Agarwal, S. S. Agrawal, R. Saxena, and N. Galpalli (2008)
Invest. Ophthalmol. Vis. Sci. 49, 4036-4040
 |  Abstract »  |  Full Text »  |  PDF »

Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation.

Y. Li, M. Komai-Koma, D. S. Gilchrist, D. K. Hsu, F.-T. Liu, T. Springall, and D. Xu (2008)
J. Immunol. 181, 2781-2789
 |  Abstract »  |  Full Text »  |  PDF »

Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice.

Y. Wang, X. Zhu, G. Wu, L. Shen, and B. Chen (2008)
J. Lipid Res. 49, 1640-1645
 |  Abstract »  |  Full Text »  |  PDF »

Prophylaxis of lipopolysaccharide-induced shock by {alpha}-galactosylceramide.

G. Sireci, M. P. La Manna, D. Di Liberto, M. Lo Dico, M. Taniguchi, F. Dieli, and A. Salerno (2008)
J. Leukoc. Biol. 84, 550-560
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Gene Expression via Disruption of NF-{kappa}B Signaling by a Bacterial Small Molecule.

V. V. Kravchenko, G. F. Kaufmann, J. C. Mathison, D. A. Scott, A. Z. Katz, D. C. Grauer, M. Lehmann, M. M. Meijler, K. D. Janda, and R. J. Ulevitch (2008)
Science 321, 259-263
 |  Abstract »  |  Full Text »  |  PDF »

First Demonstration of the Role of TNF in the Pathogenesis of Disease.

J. Vilcek (2008)
J. Immunol. 181, 5-6
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Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria.

A. Chorny, P. Anderson, E. Gonzalez-Rey, and M. Delgado (2008)
J. Immunol. 180, 8369-8377
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Hyper innate responses in neonates lead to increased morbidity and mortality after infection.

J. Zhao, K. D. Kim, X. Yang, S. Auh, Y.-X. Fu, and H. Tang (2008)
PNAS 105, 7528-7533
 |  Abstract »  |  Full Text »  |  PDF »

Surfactant protein D is expressed and modulates inflammatory responses in human coronary artery smooth muscle cells.

G. D. Snyder, R. E. Oberley-Deegan, K. L. Goss, S. A. Romig-Martin, L. L. Stoll, J. M. Snyder, and N. L. Weintraub (2008)
Am J Physiol Heart Circ Physiol 294, H2053-H2059
 |  Abstract »  |  Full Text »  |  PDF »

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1.

A. Chorny and M. Delgado (2008)
Am. J. Pathol. 172, 1297-1307
 |  Abstract »  |  Full Text »  |  PDF »

Gender dimorphism following injury: making the connection from bench to bedside.

J. L. Sperry and J. P. Minei (2008)
J. Leukoc. Biol. 83, 499-506
 |  Abstract »  |  Full Text »  |  PDF »

Sepsis: rethinking the approach to clinical research.

J. C. Marshall (2008)
J. Leukoc. Biol. 83, 471-482
 |  Abstract »  |  Full Text »  |  PDF »

The Proinflammatory Cytokine Macrophage Migration Inhibitory Factor Regulates Glucose Metabolism during Systemic Inflammation.

T. Atsumi, Y.-R. Cho, L. Leng, C. McDonald, T. Yu, C. Danton, E.-G. Hong, R. A. Mitchell, C. Metz, H. Niwa, et al. (2007)
J. Immunol. 179, 5399-5406
 |  Abstract »  |  Full Text »  |  PDF »

Role for MyD88-Independent, TRIF Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance.

S. K. Biswas, P. Bist, M. K. Dhillon, T. Kajiji, C. del Fresno, M. Yamamoto, E. Lopez-Collazo, S. Akira, and V. Tergaonkar (2007)
J. Immunol. 179, 4083-4092
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis.

V. Poulaki, E. Iliaki, N. Mitsiades, C. S. Mitsiades, Y. N. Paulus, D. V. Bula, E. S. Gragoudas, and J. W. Miller (2007)
FASEB J 21, 2113-2123
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo.

M. A. Nolte, S. LeibundGut-Landmann, O. Joffre, and C. R. e Sousa (2007)
J. Exp. Med. 204, 1487-1501
 |  Abstract »  |  Full Text »  |  PDF »

Pathophysiology of Sepsis.

D. G. Remick (2007)
Am. J. Pathol. 170, 1435-1444
 |  Abstract »  |  Full Text »  |  PDF »

Sepsis-associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice.

M. W. Laschke, M. D. Menger, Y. Wang, G. Lindell, B. Jeppsson, and H. Thorlacius (2007)
Am J Physiol Gastrointest Liver Physiol 292, G1396-G1402
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Advance: {alpha}-Galactosylceramide induces protection against lipopolysaccharide-induced shock.

G. Sireci, M. P. La Manna, C. Di Sano, D. Di Liberto, S. A. Porcelli, M. Kronenberg, F. Dieli, and A. Salerno (2007)
J. Leukoc. Biol. 81, 607-622
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an Inflammation-inducible Serum Protein Recognized by Anti-disialic Acid Antibodies as Carbonic Anhydrase II.

Z. Yasukawa, C. Sato, and K. Kitajima (2007)
J. Biochem. 141, 429-441
 |  Abstract »  |  Full Text »  |  PDF »

The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-{kappa}B activation, and TNF-{alpha} secretion in macrophages.

S. A. Parsons and P. A. Greer (2006)
J. Leukoc. Biol. 80, 1522-1528
 |  Abstract »  |  Full Text »  |  PDF »

Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality.

M. F. Osuchowski, K. Welch, J. Siddiqui, and D. G. Remick (2006)
J. Immunol. 177, 1967-1974
 |  Abstract »  |  Full Text »  |  PDF »

Immunological alterations during the clinical and recovery phases of experimental swine dysentery..

R. Jonasson, M. Andersson, T. Rasback, A. Johannisson, and M. Jensen-Waern (2006)
J. Med. Microbiol. 55, 845-855
 |  Abstract »  |  Full Text »  |  PDF »

PanR1, a Dominant Negative Missense Allele of the Gene Encoding TNF-{alpha} (Tnf), Does Not Impair Lymphoid Development..

S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B. I. Dahiyat, P. Steed, and B. Beutler (2006)
J. Immunol. 176, 7525-7532
 |  Abstract »  |  Full Text »  |  PDF »

Novel Lymphotoxin Alpha (LT{alpha}) Knockout Mice with Unperturbed Tumor Necrosis Factor Expression: Reassessing LT{alpha} Biological Functions..

D. J. Liepinsh, S. I. Grivennikov, K. D. Klarmann, M. A. Lagarkova, M. S. Drutskaya, S. J. Lockett, L. Tessarollo, M. McAuliffe, J. R. Keller, D. V. Kuprash, et al. (2006)
Mol. Cell. Biol. 26, 4214-4225
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Tissue Inhibitor of Metalloproteinase 3 Regulates TNF-Dependent Systemic Inflammation.

D. S. Smookler, F. F. Mohammed, Z. Kassiri, G. S. Duncan, T. W. Mak, and R. Khokha (2006)
J. Immunol. 176, 721-725
 |  Abstract »  |  Full Text »  |  PDF »

Lipoteichoic Acid-Induced Nitric Oxide Production Depends on the Activation of Platelet-Activating Factor Receptor and Jak2.

S. H. Han, J. H. Kim, H. S. Seo, M. H. Martin, G.-H. Chung, S. M. Michalek, and M. H. Nahm (2006)
J. Immunol. 176, 573-579
 |  Abstract »  |  Full Text »  |  PDF »

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity.

S. L. Werner, D. Barken, and A. Hoffmann (2005)
Science 309, 1857-1861
 |  Abstract »  |  Full Text »  |  PDF »

Identification of High and Low Responders to Lipopolysaccharide in Normal Subjects: An Unbiased Approach to Identify Modulators of Innate Immunity.

M. M. Wurfel, W. Y. Park, F. Radella, J. Ruzinski, A. Sandstrom, J. Strout, R. E. Bumgarner, and T. R. Martin (2005)
J. Immunol. 175, 2570-2578
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling.

K. I. Kim, O. A. Malakhova, K. Hoebe, M. Yan, B. Beutler, and D.-E. Zhang (2005)
J. Immunol. 175, 847-854
 |  Abstract »  |  Full Text »  |  PDF »

The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin.

F. P. Polack, P. M. Irusta, S. J. Hoffman, M. P. Schiatti, G. A. Melendi, M. F. Delgado, F. R. Laham, B. Thumar, R. M. Hendry, J. A. Melero, et al. (2005)
PNAS 102, 8996-9001
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide, Toll-Like Receptors, and the Immune Contribution to Atherosclerosis.

T. M. Doherty, P. K. Shah, M. Arditi, L. L. Stoll, G. M. Denning, and N. L. Weintraub (2005)
Arterioscler. Thromb. Vasc. Biol. 25, e38-e39
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Characterization of Toll-like receptors in the female reproductive tract in humans.

A. Fazeli, C. Bruce, and D.O. Anumba (2005)
Hum. Reprod. 20, 1372-1378
 |  Abstract »  |  Full Text »  |  PDF »

Anti-inflammatory response is associated with mortality and severity of infection in sepsis.

A. Ashare, L. S. Powers, N. S. Butler, K. C. Doerschug, M. M. Monick, and G. W. Hunninghake (2005)
Am J Physiol Lung Cell Mol Physiol 288, L633-L640
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Kupffer Cells After Major Liver Surgery.

H. A. Prins, C. Meijer, P. G. Boelens, R. J. Nijveldt, M. P. C. Siroen, S. Masson, M. Daveau, M. Scotte, J. Diks, and P. A. M. van Leeuwen (2005)
JPEN J Parenter Enteral Nutr 29, 48-55
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-Induced Down-Regulation of Organic Anion Transporting Polypeptide 4 (Oatp4; Slc21a10) Is Independent of Tumor Necrosis Factor-{alpha}, Interleukin-1{beta}, Interleukin-6, or Inducible Nitric Oxide Synthase.

N. Li and C. D. Klaassen (2005)
Toxicol. Sci. 83, 197-203
 |  Abstract »  |  Full Text »  |  PDF »

Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis.

L. L. Stoll, G. M. Denning, and N. L. Weintraub (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 2227-2236
 |  Abstract »  |  Full Text »  |  PDF »

PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice.

G. Schabbauer, M. Tencati, B. Pedersen, R. Pawlinski, and N. Mackman (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1963-1969
 |  Abstract »  |  Full Text »  |  PDF »

Hypothermia prolongs activation of NF-{kappa}B and augments generation of inflammatory cytokines.

K. D. Fairchild, I. S. Singh, S. Patel, B. E. Drysdale, R. M. Viscardi, L. Hester, H. M. Lazusky, and J. D. Hasday (2004)
Am J Physiol Cell Physiol 287, C422-C431
 |  Abstract »  |  Full Text »  |  PDF »

Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats.

T. Nedrebo, R. K. Reed, R. Jonsson, A. Berg, and H. Wiig (2004)
J. Physiol. 556, 193-202
 |  Abstract »  |  Full Text »  |  PDF »

Distinct pathways of LPS-induced NF-{kappa}B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

E. Andreakos, S. M. Sacre, C. Smith, A. Lundberg, S. Kiriakidis, T. Stonehouse, C. Monaco, M. Feldmann, and B. M. Foxwell (2004)
Blood 103, 2229-2237
 |  Abstract »  |  Full Text »  |  PDF »

Shielding the double-edged sword: negative regulation of the innate immune system.

K. S. Kobayashi and R. A. Flavell (2004)
J. Leukoc. Biol. 75, 428-433
 |  Abstract »  |  Full Text »  |  PDF »

Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-{alpha} (TNF-{alpha}) gene expression.

A.-L. Bolcato-Bellemin, M.-G. Mattei, M. Fenton, and S. Amar (2004)
Innate Immunity 10, 15-23
 |  Abstract »  |  PDF »

TNF-{alpha} induces a decrease in eNOS promoter activity.

P. Neumann, N. Gertzberg, and A. Johnson (2004)
Am J Physiol Lung Cell Mol Physiol 286, L452-L459
 |  Abstract »  |  Full Text »  |  PDF »

The role of STAT1 in viral sensitization to LPS.

J. Durbin, L. Doughty, K. Nguyen, M. Caligiuri, J. Van Deusen, and C. Biron (2003)
Innate Immunity 9, 313-316
 |  Abstract »  |  PDF »

Effect of Human Cationic Antimicrobial Protein 18 Peptide on Endotoxin-Induced Uveitis in Rats.

K. Ohgami, I. B. Ilieva, K. Shiratori, E. Isogai, K. Yoshida, S. Kotake, T. Nishida, N. Mizuki, and S. Ohno (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4412-4418
 |  Abstract »  |  Full Text »  |  PDF »

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.

K. Hoebe, Xin Du, J. Goode, N. Mann, and B. Beutler (2003)
Innate Immunity 9, 250-255
 |  Abstract »  |  PDF »

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock.

E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper (2003)
Clin. Microbiol. Rev. 16, 379-414
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Lapachone Reduces Endotoxin-induced Macrophage Activation and Lung Edema and Mortality.

H.-P. Tzeng, F.-M. Ho, K.-F. Chao, M.-L. Kuo, S.-Y. Lin-Shiau, and S.-H. Liu (2003)
Am. J. Respir. Crit. Care Med. 168, 85-91
 |  Abstract »  |  Full Text »  |  PDF »

Safety, Pharmacokinetics, and Pharmacodynamics of E5564, a Lipid A Antagonist, during an Ascending Single-Dose Clinical Study.

Y. N. Wong, D. Rossignol, J. R. Rose, R. Kao, A. Carter, and M. Lynn (2003)
J. Clin. Pharmacol. 43, 735-742
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Lipopolysaccharide Sensitivity by IFN Regulatory Factor-2.

N. Cuesta, C. A. Salkowski, K. E. Thomas, and S. N. Vogel (2003)
J. Immunol. 170, 5739-5747
 |  Abstract »  |  Full Text »  |  PDF »

TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes.

T. Pedron, R. Girard, and R. Chaby (2003)
J. Biol. Chem. 278, 20555-20564
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous versus exogenous glucocorticoid responses to experimental bacterial sepsis.

R. Silverstein and D. C. Johnson (2003)
J. Leukoc. Biol. 73, 417-427
 |  Abstract »  |  Full Text »  |  PDF »

Cu/Zn Superoxide Dismutase Plays Important Role in Immune Response.

M. Marikovsky, V. Ziv, N. Nevo, C. Harris-Cerruti, and O. Mahler (2003)
J. Immunol. 170, 2993-3001
 |  Abstract »  |  Full Text »  |  PDF »

Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.

A. Siflinger-Birnboim and A. Johnson (2003)
Am J Physiol Lung Cell Mol Physiol 284, L435-L451
 |  Abstract »  |  Full Text »  |  PDF »

Ikappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.

D. L. Carlson, D. J. White, D. L. Maass, R. C. Nguyen, B. Giroir, and J. W. Horton (2003)
Am J Physiol Heart Circ Physiol 284, H804-H814
 |  Abstract »  |  Full Text »  |  PDF »

Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-{alpha} Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner.

T. Morichika, H. K. Takahashi, H. Iwagaki, T. Yoshino, R. Tamura, M. Yokoyama, S. Mori, T. Akagi, M. Nishibori, and N. Tanaka (2003)
J. Pharmacol. Exp. Ther. 304, 624-633
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Nuclear Factor-{kappa}B by Corticotropin-Releasing Hormone in Mouse Thymocytes.

J. Zhao and K. P. Karalis (2002)
Mol. Endocrinol. 16, 2561-2570
 |  Abstract »  |  Full Text »  |  PDF »

Risk and the Efficacy of Antiinflammatory Agents: Retrospective and Confirmatory Studies of Sepsis.

P. Q. Eichacker, C. Parent, A. Kalil, C. Esposito, X. Cui, S. M. Banks, E. P. Gerstenberger, Y. Fitz, R. L. Danner, and C. Natanson (2002)
Am. J. Respir. Crit. Care Med. 166, 1197-1205
 |  Abstract »  |  Full Text »  |  PDF »

Review paper: LPS in microbial pathogenesis: promise and fulfilment.

B. Beutler (2002)
Innate Immunity 8, 329-335
 |  Abstract »  |  PDF »

Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues.

I. Nagaoka, S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, S. Tanaka, and D. Heumann (2002)
Clin. Vaccine Immunol. 9, 972-982
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-10 Controls the Onset of Irreversible Septic Shock.

S. Q. Latifi, M. A. O'Riordan, and A. D. Levine (2002)
Infect. Immun. 70, 4441-4446
 |  Abstract »  |  Full Text »  |  PDF »

Pretreatment with troglitazone decreases lethality during endotoxemia in mice.

K. Reynolds, B. Novosad, A. Hoffhines, J. Gipson, J. Johnson, J. Peters, F. Gonzalez, J. Gimble, and M. Hill (2002)
Innate Immunity 8, 307-314
 |  Abstract »  |  PDF »

Critical Role of NK Cells Rather Than V{alpha}14+NKT Cells in Lipopolysaccharide-Induced Lethal Shock in Mice.

M. Emoto, M. Miyamoto, I. Yoshizawa, Y. Emoto, U. E. Schaible, E. Kita, and S. H. E. Kaufmann (2002)
J. Immunol. 169, 1426-1432
 |  Abstract »  |  Full Text »  |  PDF »

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

J. Staelens, B. Wielockx, L. Puimege, F. Van Roy, J.-L. Guenet, and C. Libert (2002)
PNAS 99, 9340-9345
 |  Abstract »  |  Full Text »  |  PDF »

Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model.

M. U. Purswani, S. J. Eckert, H. K. Arora, and G. J. Noel (2002)
J. Antimicrob. Chemother. 50, 51-58
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial Peptidoglycan-associated Lipoprotein Is Released into the Bloodstream in Gram-negative Sepsis and Causes Inflammation and Death in Mice.

J. Hellman, J. D. Roberts Jr., M. M. Tehan, J. E. Allaire, and H. S. Warren (2002)
J. Biol. Chem. 277, 14274-14280
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac Inflammation and Innate Immunity in Septic Shock* : Is There a Role for Toll-Like Receptors?.

P. Knuefermann, S. Nemoto, G. Baumgarten, A. Misra, N. Sivasubramanian, B. A. Carabello, and J. G. Vallejo (2002)
Chest 121, 1329-1336
 |  Abstract »  |  Full Text »  |  PDF »

A High Affinity HSF-1 Binding Site in the 5'-Untranslated Region of the Murine Tumor Necrosis Factor-alpha Gene Is a Transcriptional Repressor.

I. S. Singh, J.-R. He, S. Calderwood, and J. D. Hasday (2002)
J. Biol. Chem. 277, 4981-4988
 |  Abstract »  |  Full Text »  |  PDF »

Biological Characterization of Lipopolysaccharide from Treponema pectinovorum.

L. Kesavalu, C. W. Falk, K. J. Davis, M. J. Steffen, X. Xu, S. C. Holt, and J. L. Ebersole (2002)
Infect. Immun. 70, 211-217
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Deficiency of Tumor Necrosis Factor Alpha or Both of Its Receptors on Streptococcus pneumoniae Central Nervous System Infection and Peritonitis.

A. Wellmer, J. Gerber, J. Ragheb, G. Zysk, T. Kunst, A. Smirnov, W. Bruck, and R. Nau (2001)
Infect. Immun. 69, 6881-6886
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Analysis of Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Activity in Serum and Lethality in Mice and Rabbits Pretreated with the Staphylococcal Superantigen Toxic Shock Syndrome Toxin 1.

M. M. Dinges and P. M. Schlievert (2001)
Infect. Immun. 69, 7169-7172
 |  Abstract »  |  Full Text »  |  PDF »

Heat Shock Proteins and Cardiovascular Pathophysiology.

L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van der Vusse (2001)
Physiol Rev 81, 1461-1497
 |  Abstract »  |  Full Text »  |  PDF »

Cathelicidin Family of Antibacterial Peptides CAP18 and CAP11 Inhibit the Expression of TNF-{alpha} by Blocking the Binding of LPS to CD14+ Cells.

I. Nagaoka, S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, and D. Heumann (2001)
J. Immunol. 167, 3329-3338
 |  Abstract »  |  Full Text »  |  PDF »

IL-1{alpha} and TNF{alpha} Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart.

S. C. Coste, K. A. Heldwein, S. L. Stevens, E. Tobar-Dupres, and M. P. Stenzel-Poore (2001)
Endocrinology 142, 3537-3545
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: Bacterial lipopolysaccharides and innate immunity.

C. Alexander and E. Th. Rietschel (2001)
Innate Immunity 7, 167-202
 |  Abstract »  |  PDF »

Countervailing Influence of Tumor Necrosis Factor-{{alpha}} and Nitric Oxide in Endotoxemia.

E. A. JAIMES, D. D. CASTILLO, M. S. RUTHERFORD, and L. RAIJ (2001)
J. Am. Soc. Nephrol. 12, 1204-1210
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Induction of TNF-{alpha} and MnSOD by endotoxin: role of membrane CD14 and Toll-like receptor-4.

M.-F. Tsan, R. N. Clark, S. M. Goyert, and J. E. White (2001)
Am J Physiol Cell Physiol 280, C1422-C1430
 |  Abstract »  |  Full Text »  |  PDF »

Role of ecNOS-derived NO in mediating TNF-induced endothelial barrier dysfunction.

K. Bove, P. Neumann, N. Gertzberg, and A. Johnson (2001)
Am J Physiol Lung Cell Mol Physiol 280, L914-L922
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators.

M. D. Lehner, S. Morath, K. S. Michelsen, R. R. Schumann, and T. Hartung (2001)
J. Immunol. 166, 5161-5167
 |  Abstract »  |  Full Text »  |  PDF »

The Sole Gateway to Endotoxin Response: How Lps Was Identified as Tlr4, and Its Role in Innate Immunity.

B. Beutler and A. Poltorak (2001)
Drug Metab. Dispos. 29, 474-478
 |  Abstract »  |  Full Text »

Role of Tumor Necrosis Factor on Toxicity and Cytokine Production after Isolated Hepatic Perfusion.

T. E. Lans, D. L. Bartlett, S. K. Libutti, M. F.X. Gnant, D. J. Liewehr, D. J. Venzon, E. M. Turner, and H. R. Alexander (2001)
Clin. Cancer Res. 7, 784-790
 |  Abstract »  |  Full Text »

Role of T Cells and Gamma Interferon during Induction of Hypersensitivity to Lipopolysaccharide by Toxic Shock Syndrome Toxin 1 in Mice.

M. M. Dinges and P. M. Schlievert (2001)
Infect. Immun. 69, 1256-1264
 |  Abstract »  |  Full Text »  |  PDF »

A Role for IFN-{{alpha}}{{beta}} in Virus Infection-Induced Sensitization to Endotoxin.

L. A. Doughty, K. B. Nguyen, J. E. Durbin, and C. A. Biron (2001)
J. Immunol. 166, 2658-2664
 |  Abstract »  |  Full Text »  |  PDF »

Differential Induction of TNF-{alpha} and MnSOD by Endotoxin . Role of Reactive Oxygen Species and NADPH Oxidase.

J. E. White and M.-F. Tsan (2001)
Am. J. Respir. Cell Mol. Biol. 24, 164-169
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A common regulatory locus affects both HNF4/HNF1(&agr;) pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells.

G. Bulla, E Givens, S Brown, B Oladiran, and D Kraus (2001)
J. Cell Sci. 114, 1205-1212
 |  Abstract »  |  PDF »

Improved Innate Immunity of Endotoxin-Tolerant Mice Increases Resistance to Salmonella enterica Serovar Typhimurium Infection despite Attenuated Cytokine Response.

M. D. Lehner, J. Ittner, D. S. Bundschuh, N. van Rooijen, A. Wendel, and T. Hartung (2001)
Infect. Immun. 69, 463-471
 |  Abstract »  |  Full Text »  |  PDF »

CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression.

P.-Y. Perera, T. N. Mayadas, O. Takeuchi, S. Akira, M. Zaks-Zilberman, S. M. Goyert, and S. N. Vogel (2001)
J. Immunol. 166, 574-581
 |  Abstract »  |  Full Text »  |  PDF »

Increased Resistance Against Acute Polymicrobial Sepsis in Mice Challenged with Immunostimulatory CpG Oligodeoxynucleotides Is Related to an Enhanced Innate Effector Cell Response.

H. Weighardt, C. Feterowski, M. Veit, M. Rump, H. Wagner, and B. Holzmann (2000)
J. Immunol. 165, 4537-4543
 |  Abstract »  |  Full Text »  |  PDF »

TNF-alpha dependent production of inducible nitric oxide is involved in PGE1 protection against acute liver injury.

J Muntane, F J Rodriguez, O Segado, A Quintero, J M Lozano, E Siendones, C A Pedraza, M Delgado, F O'Valle, R Garcia, et al. (2000)
Gut 47, 553-562
 |  Abstract »  |  Full Text »  |  PDF »

Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor {alpha} in rats.

T. Utsunomiya, S. R Chavali, W W. Zhong, and R A. Forse (2000)
Am. J. Clinical Nutrition 72, 804-808
 |  Abstract »  |  Full Text »  |  PDF »

Does Inhibition of Tumor Necrosis Factor Alpha Affect Chlamydial Genital Tract Infection in Mice and Guinea Pigs?.

T. Darville, C. W. Andrews Jr., and R. G. Rank (2000)
Infect. Immun. 68, 5299-5305
 |  Abstract »  |  Full Text »  |  PDF »

Bile Mediates Intestinal Pathology in Endotoxemia in Rats.

G. D. F. Jackson, Y. Dai, and W. A. Sewell (2000)
Infect. Immun. 68, 4714-4719
 |  Abstract »  |  Full Text »  |  PDF »

Review: The search for Lps: 1993--1998.

B. Beutler and A. Poltorak (2000)
Innate Immunity 6, 269-293
 |  Abstract »  |  PDF »

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