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Science 23 August 1985:
Vol. 229. no. 4715, pp. 784 - 786
DOI: 10.1126/science.3875152
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Articles

Science, Vol 229, Issue 4715, 784-786
Copyright © 1985 by American Association for the Advancement of Science

articles

Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias

J Erikson, DL Williams, J Finan, PC Nowell, and CM Croce

Mouse lymphoma cells were hybridized with two human acute T-cell leukemias with a t(11;14) (p13;q11) translocation and the segregated hybrids were examined for the presence of the DNA segments coding for the constant (C) and the variable (V) regions of the alpha chain (C alpha and V alpha) of the T-cell receptor. The C alpha segment was translocated to the involved chromosome 11 (11p+) while the V alpha segment remained on the involved chromosome 14 (14q-). The data indicate that the locus for the alpha chain of the T-cell receptor is split by the chromosomal breakpoint between the V alpha and the C alpha gene segments, and that the V alpha segments are proximal to the C alpha segment within chromosome band 14q11.2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia.
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Identification of an amplified, highly expressed gene in a human glioma.
K. Kinzler, S. Bigner, D. Bigner, J. Trent, M. Law, S. O'Brien, A. Wong, and B Vogelstein (1987)
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The molecular genetics of cancer.
J. Bishop (1987)
Science 235, 305-311
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A common mechanism of chromosomal translocation in T- and B-cell neoplasia.
L. Finger, R. Harvey, R. Moore, L. Showe, and C. Croce (1986)
Science 234, 982-985
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Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development.
C. Denny, G. Hollis, F Hecht, R Morgan, M. Link, S. Smith, and I. Kirsch (1986)
Science 234, 197-200
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Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias.
J Erikson, L Finger, L Sun, A ar-Rushdi, K Nishikura, J Minowada, J Finan, B. Emanuel, P. Nowell, and C. Croce (1986)
Science 232, 884-886
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Chronic Leukemias: Oncogenes, Chromosomes, and Advances in Therapy.
R. CHAMPLIN, R. P. GALE, K. A. FOON, and D. W. GOLDE (1986)
Ann Intern Med 104, 671-688
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Molecular Genetics of Human B- and T-cell Neoplasia.
C.M. Croce, J. Erikson, F.G. Haluska, L.R. Finger, L.C. Showe, and Y. Tsujimoto (1986)
Cold Spring Harb Symp Quant Biol 51, 891-898
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