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Science 23 August 1985:
Vol. 229. no. 4715, pp. 774 - 776
DOI: 10.1126/science.2992085
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Articles

Science, Vol 229, Issue 4715, 774-776
Copyright © 1985 by American Association for the Advancement of Science

articles

Regeneration of functional synapses between individual recognizable neurons in the lamprey spinal cord

SA Mackler and ME Selzer

In 4- to 5-year-old sea lamprey larvae that had recovered from complete transection of the spinal cord, pairs of giant interneurons on opposite sides of the scar were impaled with microelectrodes. In 4 of 30 pairs, stimulation of the caudal cell elicited a monosynaptic electrochemical excitatory postsynaptic potential in the rostral cell. Fifty percent of such pairs were synaptically linked in control lampreys without transections. These results show regeneration of functional synaptic connections between individual neurons in a vertebrate central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms of Functional Recovery in Traumatic Brain Injury.
M. E. Selzer (1995)
Neurorehabil Neural Repair 9, 73-82
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Regenerative Potential of the Spinal Cord.
M. E. Selzer (1994)
Neurorehabil Neural Repair 8, 11-15
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Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons.
S. Keirstead, M Rasminsky, Y Fukuda, D. Carter, A. Aguayo, and M Vidal-Sanz (1989)
Science 246, 255-257
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Science. ISSN 0036-8075 (print), 1095-9203 (online)