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Science 23 August 1985:
Vol. 229. no. 4715, pp. 769 - 772
DOI: 10.1126/science.4023711
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Articles

Science, Vol 229, Issue 4715, 769-772
Copyright © 1985 by American Association for the Advancement of Science

articles

Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy

PA Bottomley

Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative concentrations of high-energy phosphate metabolites have been recorded noninvasively from the human heart in vivo. Spectral data were spatially localized by combining a pulsed magnetic field gradient with surface NMR excitation-detection coils. The location of the selected spectral region was determined by conventional proton NMR imaging immediately before examination by phosphorus-31 NMR spectroscopy.


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