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Science 23 August 1985:
Vol. 229. no. 4715, pp. 767 - 769
DOI: 10.1126/science.3860954
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Articles

Science, Vol 229, Issue 4715, 767-769
Copyright © 1985 by American Association for the Advancement of Science

articles

The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia

MO Diaz, MM Le Beau, JD Rowley, HA Drabkin, and D Patterson

The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Trisomy 8 Mosaicism Syndrome: Two Cases Demonstrating Variability in Phenotype.
Z. E. Kurtyka, B. Krzykwa, E. Piatkowska, M. Radwan, and J. J. Pietrzyk (1988)
Clinical Pediatrics 27, 557-564
   Abstract »    PDF »
Syndromes of Acute Nonlymphocytic Leukemia.
H. P. KOEFFLER (1987)
Ann Intern Med 107, 748-758
   Abstract »    PDF »


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