Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 August 1985:
Vol. 229. no. 4714, pp. 675 - 679
DOI: 10.1126/science.2992082
Prev | Table of Contents | Next

Articles

Science, Vol 229, Issue 4714, 675-679
Copyright © 1985 by American Association for the Advancement of Science

articles

The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats

BK Felber, H Paskalis, C Kleinman-Ewing, F Wong-Staal, and GN Pavlakis

Expression of the pX protein of human T-cell leukemia virus type I (HTLV-I) in animal cells demonstrates that this protein is a specific transcriptional activator of the long terminal repeats (LTR) of HTLV-I. Several other promoters are not affected by pX. No lymphocyte-specific factors are required for this activation. pX can be detected in the nucleus of transfected monkey kidney cells (line CV1) by indirect immunofluorescence. These results indicate that the pX protein is essential for the replication cycle of the virus and that it may be directly involved in the immortalization of human lymphocytes by HTLV-I.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo.
M. Kesic, M. Ward, O. J. Semmes, and P. L. Green (2009)
J. Virol. 83, 8859-8868
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication.
L. Xie, M. Kesic, B. Yamamoto, M. Li, I. Younis, M. D. Lairmore, and P. L. Green (2009)
J. Virol. 83, 5232-5243
   Abstract »    Full Text »    PDF »
Kinetic Analysis of Human T-Cell Leukemia Virus Type 1 Gene Expression in Cell Culture and Infected Animals.
M. Li, M. Kesic, H. Yin, L. Yu, and P. L. Green (2009)
J. Virol. 83, 3788-3797
   Abstract »    Full Text »    PDF »
Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo.
M. Z. Dewan, N. Takamatsu, T. Hidaka, K. Hatakeyama, S. Nakahata, J.-i. Fujisawa, H. Katano, N. Yamamoto, and K. Morishita (2008)
J. Virol. 82, 11958-11963
   Abstract »    Full Text »    PDF »
Analysis of the Interaction of Primate Retroviruses with the Human RNA Interference Machinery.
J. Lin and B. R. Cullen (2007)
J. Virol. 81, 12218-12226
   Abstract »    Full Text »    PDF »
Modulation of the Brd4/P-TEFb Interaction by the Human T-Lymphotropic Virus Type 1 Tax Protein.
W.-K. Cho, M. Zhou, M. K. Jang, K. Huang, S.-J. Jeong, K. Ozato, and J. N. Brady (2007)
J. Virol. 81, 11179-11186
   Abstract »    Full Text »    PDF »
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
J.-C. Twizere, J.-Y. Springael, M. Boxus, A. Burny, F. Dequiedt, J.-F. Dewulf, J. Duchateau, D. Portetelle, P. Urbain, C. V. Lint, et al. (2007)
Blood 109, 1051-1060
   Abstract »    Full Text »    PDF »
Tax Interacts with P-TEFb in a Novel Manner To Stimulate Human T-Lymphotropic Virus Type 1 Transcription..
M. Zhou, H. Lu, H. Park, J. Wilson-Chiru, R. Linton, and J. N. Brady (2006)
J. Virol. 80, 4781-4791
   Abstract »    Full Text »    PDF »
PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo.
L. Xie, B. Yamamoto, A. Haoudi, O. J. Semmes, and P. L. Green (2006)
Blood 107, 1980-1988
   Abstract »    Full Text »    PDF »
Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.
M. Z. Dewan, J.-n. Uchihara, K. Terashima, M. Honda, T. Sata, M. Ito, N. Fujii, K. Uozumi, K. Tsukasaki, M. Tomonaga, et al. (2006)
Blood 107, 716-724
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Open Reading Frame II Encodes a Posttranscriptional Repressor That Is Recruited at the Level of Transcription.
I. Younis, K. Boris-Lawrie, and P. L. Green (2006)
J. Virol. 80, 181-191
   Abstract »    Full Text »    PDF »
Envelope Is a Major Viral Determinant of the Distinct In Vitro Cellular Transformation Tropism of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2.
L. Xie and P. L. Green (2005)
J. Virol. 79, 14536-14545
   Abstract »    Full Text »    PDF »
A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions.
S. Awasthi, A. Sharma, K. Wong, J. Zhang, E. F. Matlock, L. Rogers, P. Motloch, S. Takemoto, H. Taguchi, M. D. Cole, et al. (2005)
Mol. Cell. Biol. 25, 6178-6198
   Abstract »    Full Text »    PDF »
The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription.
E. Forgacs, S. K. Gupta, J. A. Kerry, and O. J. Semmes (2005)
J. Virol. 79, 6932-6939
   Abstract »    Full Text »    PDF »
Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator.
I. Younis, L. Khair, M. Dundr, M. D. Lairmore, G. Franchini, and P. L. Green (2004)
J. Virol. 78, 11077-11083
   Abstract »    Full Text »    PDF »
A 10-Amino Acid Domain within Human T-cell Leukemia Virus Type 1 and Type 2 Tax Protein Sequences Is Responsible for Their Divergent Subcellular Distribution.
L. Meertens, S. Chevalier, R. Weil, A. Gessain, and R. Mahieux (2004)
J. Biol. Chem. 279, 43307-43320
   Abstract »    Full Text »    PDF »
Repression of Tax Expression Is Associated both with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Killing by Tax-Specific Cytotoxic T Lymphocytes and with Impaired Tumorigenicity in a Rat Model.
M. Nomura, T. Ohashi, K. Nishikawa, H. Nishitsuji, K. Kurihara, A. Hasegawa, R. A. Furuta, J.-i. Fujisawa, Y. Tanaka, S. Hanabuchi, et al. (2004)
J. Virol. 78, 3827-3836
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+ Cells In Vitro.
A. Tripp, Y. Liu, M. Sieburg, J. Montalbano, S. Wrzesinski, and G. Feuer (2003)
J. Virol. 77, 12152-12164
   Abstract »    Full Text »    PDF »
T-Cell Receptor/CD28 Engagement When Combined with Prostaglandin E2 Treatment Leads to Potent Activation of Human T-Cell Leukemia Virus Type 1.
N. Dumais, M.-E. Pare, S. Mercier, S. Bounou, S. J. Marriot, B. Barbeau, and M. J. Tremblay (2003)
J. Virol. 77, 11170-11179
   Abstract »    Full Text »    PDF »
SR-Related Protein TAXREB803/SRL300 Is an Important Cellular Factor for the Transactivational Function of Human T-Cell Lymphotropic Virus Type 1 Tax.
H.-G. Youn, J. Matsumoto, Y. Tanaka, and K. Shimotohno (2003)
J. Virol. 77, 10015-10027
   Abstract »    Full Text »    PDF »
Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/{gamma}cnull Mice: Suppression by an Inhibitor against NF-{kappa}B.
M. Z. Dewan, K. Terashima, M. Taruishi, H. Hasegawa, M. Ito, Y. Tanaka, N. Mori, T. Sata, Y. Koyanagi, M. Maeda, et al. (2003)
J. Virol. 77, 5286-5294
   Abstract »    Full Text »    PDF »
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element.
N. Hiraiwa, T. Yabuta, K. Yoritomi, M. Hiraiwa, Y. Tanaka, T. Suzuki, M. Yoshida, and R. Kannagi (2003)
Blood 101, 3615-3621
   Abstract »    Full Text »    PDF »
Reactivation of a complex retrovirus is controlled by a molecular switch and is inhibited by a viral protein.
C. D. Meiering and M. L. Linial (2002)
PNAS 99, 15130-15135
   Abstract »    Full Text »    PDF »
Correlation of Major Histocompatibility Complex Class I Downregulation with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Cytotoxic T-Lymphocyte Killing in a Rat Model.
T. Ohashi, S. Hanabuchi, R. Suzuki, H. Kato, T. Masuda, and M. Kannagi (2002)
J. Virol. 76, 7010-7019
   Abstract »    Full Text »    PDF »
Inhibition of the Tax-Dependent Human T-Lymphotropic Virus Type I Replication in Persistently Infected Cells by the Fluoroquinolone Derivative K-37.
X. Wang, H. Miyake, M. Okamoto, M. Saito, J.-I. Fujisawa, Y. Tanaka, S. Izumo, and M. Baba (2002)
Mol. Pharmacol. 61, 1359-1365
   Abstract »    Full Text »    PDF »
IFN Regulatory Factor 4 Participates in the Human T Cell Lymphotropic Virus Type I-Mediated Activation of the IL-15 Receptor {alpha} Promoter.
J. M. Mariner, Y. Mamane, J. Hiscott, T. A. Waldmann, and N. Azimi (2002)
J. Immunol. 168, 5667-5674
   Abstract »    Full Text »    PDF »
Mutant Tax Protein from Bovine Leukemia Virus with Enhanced Ability To Activate the Expression of c-fos.
S. Tajima and Y. Aida (2002)
J. Virol. 76, 2557-2562
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax.
K. Endo, A. Hirata, K. Iwai, M. Sakurai, M. Fukushi, M. Oie, M. Higuchi, W. W. Hall, F. Gejyo, and M. Fujii (2002)
J. Virol. 76, 2648-2653
   Abstract »    Full Text »    PDF »
Mouse Model for the Equilibration Interaction between the Host Immune System and Human T-Cell Leukemia Virus Type 1 Gene Expression.
R. A. Furuta, K. Sugiura, S. Kawakita, T. Inada, S. Ikehara, T. Matsuda, and J.-i. Fujisawa (2002)
J. Virol. 76, 2703-2713
   Abstract »    Full Text »    PDF »
p300-Mediated Tax Transactivation from Recombinant Chromatin: Histone Tail Deletion Mimics Coactivator Function.
S. A. Georges, W. L. Kraus, K. Luger, J. K. Nyborg, and P. J. Laybourn (2002)
Mol. Cell. Biol. 22, 127-137
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum and cis-Golgi Localization of Human T-Lymphotropic Virus Type 1 p12I: Association with Calreticulin and Calnexin.
W. Ding, B. Albrecht, R. Luo, W. Zhang, J. R. L. Stanley, G. C. Newbound, and M. D. Lairmore (2001)
J. Virol. 75, 7672-7682
   Abstract »    Full Text »    PDF »
Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction.
M. D. Robek and L. Ratner (2000)
J. Virol. 74, 11988-11992
   Abstract »    Full Text »
The Region between Amino Acids 245 and 265 of the Bovine Leukemia Virus (BLV) Tax Protein Restricts Transactivation Not Only via the BLV Enhancer but Also via Other Retrovirus Enhancers.
S. Tajima and Y. Aida (2000)
J. Virol. 74, 10939-10949
   Abstract »    Full Text »
Prevention of Adult T-Cell Leukemia-Like Lymphoproliferative Disease in Rats by Adoptively Transferred T Cells from a Donor Immunized with Human T-Cell Leukemia Virus Type 1 Tax-Coding DNA Vaccine.
T. Ohashi, S. Hanabuchi, H. Kato, H. Tateno, F. Takemura, T. Tsukahara, Y. Koya, A. Hasegawa, T. Masuda, and M. Kannagi (2000)
J. Virol. 74, 9610-9616
   Abstract »    Full Text »
In Vivo Genomic Footprinting of the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Long Terminal Repeat Enhancer Sequences in HTLV-1-Infected Human T-Cell Lines with Different Levels of Tax I Activity.
S. Datta, N. H. Kothari, and H. Fan (2000)
J. Virol. 74, 8277-8285
   Abstract »    Full Text »
Molecular Interactions Involved in the Transactivation of the Human T-Cell Leukemia Virus Type 1 Promoter Mediated by Tax and CREB-2 (ATF-4).
F. Gachon, S. Thebault, A. Peleraux, C. Devaux, and J.-M. Mesnard (2000)
Mol. Cell. Biol. 20, 3470-3481
   Abstract »    Full Text »
Cell Type-specific E2F Activation and Cell Cycle Progression Induced by the Oncogene Product Tax of Human T-cell Leukemia Virus Type I.
K. Ohtani, R. Iwanaga, M. Arai, Y. Huang, Y. Matsumura, and M. Nakamura (2000)
J. Biol. Chem. 275, 11154-11163
   Abstract »    Full Text »    PDF »
Initiation of translation by non-AUG codons in human T-cell lymphotropic virus type I mRNA encoding both Rex and Tax regulatory proteins.
S. Corcelette, T. Masse, and J.-J. Madjar (2000)
Nucleic Acids Res. 28, 1625-1634
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets.
M. Burton, C. D. Upadhyaya, B. Maier, T. J. Hope, and O. J. Semmes (2000)
J. Virol. 74, 2351-2364
   Abstract »    Full Text »
The EICP22 Protein of Equine Herpesvirus 1 Physically Interacts with the Immediate-Early Protein and with Itself To Form Dimers and Higher-Order Complexes.
W. A. Derbigny, S. K. Kim, G. B. Caughman, and D. J. O'Callaghan (2000)
J. Virol. 74, 1425-1435
   Abstract »    Full Text »
Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-kappa B in Apoptosis-Resistant T-Cell Transfectants with Tax.
T. Tsukahara, M. Kannagi, T. Ohashi, H. Kato, M. Arai, G. Nunez, Y. Iwanaga, N. Yamamoto, K. Ohtani, M. Nakamura, et al. (1999)
J. Virol. 73, 7981-7987
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 2 Rex Protein Increases Stability and Promotes Nuclear to Cytoplasmic Transport of gag/pol and env RNAs.
K. Kusuhara, M. Anderson, S. M. Pettiford, and P. L. Green (1999)
J. Virol. 73, 8112-8119
   Abstract »    Full Text »    PDF »
Immortalization of CD4+ and CD8+ T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone.
M. D. Robek and L. Ratner (1999)
J. Virol. 73, 4856-4865
   Abstract »    Full Text »
Interaction of Gli2 with CREB Protein on DNA Elements in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type 1 Is Responsible for Transcriptional Activation by Tax Protein.
S. Dan, A. Tanimura, and M. Yoshida (1999)
J. Virol. 73, 3258-3263
   Abstract »    Full Text »
Constitutive Activation of NF-kappa B in Primary Adult T-Cell Leukemia Cells.
N. Mori, M. Fujii, S. Ikeda, Y. Yamada, M. Tomonaga, D. W. Ballard, and N. Yamamoto (1999)
Blood 93, 2360-2368
   Abstract »    Full Text »    PDF »
Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling.
V. Doucas and R. M. Evans (1999)
PNAS 96, 2633-2638
   Abstract »    Full Text »    PDF »
In Vivo Rescue of a Silent tax-Deficient Bovine Leukemia Virus from a Tumor-Derived Ovine B-Cell Line by Recombination with a Retrovirally Transduced Wild-Type tax Gene.
A. Van Den Broeke, C. Bagnis, M. Ciesiolka, Y. Cleuter, H. Gelderblom, P. Kerkhofs, P. Griebel, P. Mannoni, and A. Burny (1999)
J. Virol. 73, 1054-1065
   Abstract »    Full Text »
Phosphorylation of the Human T-Cell Leukemia Virus Type 1 Transactivator Tax on Adjacent Serine Residues Is Critical for Tax Activation.
F. Bex, K. Murphy, R. Wattiez, A. Burny, and R. B. Gaynor (1999)
J. Virol. 73, 738-745
   Abstract »    Full Text »    PDF »
The Coactivator CBP Stimulates Human T-cell Lymphotrophic Virus Type I Tax Transactivation in Vitro.
F. Kashanchi, J. F. Duvall, R. P. S. Kwok, J. R. Lundblad, R. H. Goodman, and J. N. Brady (1998)
J. Biol. Chem. 273, 34646-34652
   Abstract »    Full Text »    PDF »
Complete Bovine Leukemia Virus (BLV) Provirus Is Conserved in BLV-Infected Cattle throughout the Course of B-Cell Lymphosarcoma Development.
S. Tajima, Y. Ikawa, and Y. Aida (1998)
J. Virol. 72, 7569-7576
   Abstract »    Full Text »    PDF »
The Human T-cell Leukemia Virus-1 Transcriptional Activator Tax Enhances cAMP-responsive Element-binding Protein (CREB) Binding Activity through Interactions with the DNA Minor Groove.
J. R. Lundblad, R. P. S. Kwok, M. E. Laurance, M. S. Huang, J. P. Richards, R. G. Brennan, and R. H. Goodman (1998)
J. Biol. Chem. 273, 19251-19259
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I.
K. Ohtani, A. Tsujimoto, T. Tsukahara, N. Numata, S. Miura, K. Sugamura, and M. Nakamura (1998)
J. Biol. Chem. 273, 14119-14129
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb.
C. Neuveut, K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and K.-T. Jeang (1998)
Mol. Cell. Biol. 18, 3620-3632
   Abstract »    Full Text »
Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome.
A. Tanimura, S. Dan, and M. Yoshida (1998)
J. Virol. 72, 3958-3964
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 pX-I and pX-II Open Reading Frames Are Dispensable for the Immortalization of Primary Lymphocytes.
M. D. Robek, F.-H. Wong, and L. Ratner (1998)
J. Virol. 72, 4458-4462
   Abstract »    Full Text »    PDF »
The Tax Protein of Human T-cell Leukemia Virus Type 1 Mediates the Transactivation of the c-sis/Platelet-derived Growth Factor-B Promoter through Interactions with the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1.
S. R. Trejo, W. E. Fahl, and L. Ratner (1997)
J. Biol. Chem. 272, 27411-27421
   Abstract »    Full Text »    PDF »
Identification of an Osteoclast Transcription Factor That Binds to the Human T Cell Leukemia Virus Type I-Long Terminal Repeat Enhancer Element.
D. Inoue, P. Santiago, W. C. Horne, and R. Baron (1997)
J. Biol. Chem. 272, 25386-25393
   Abstract »    Full Text »    PDF »
Differential Activation of Viral and Cellular Promoters by Human T-cell Lymphotropic Virus-1 Tax and cAMP-responsive Element Modulator Isoforms.
M. E. Laurance, R. P.S. Kwok, M. S. Huang, J. P. Richards, J. R. Lundblad, and R. H. Goodman (1997)
J. Biol. Chem. 272, 2646-2651
   Abstract »    Full Text »    PDF »
Evidence for the Participation of Interleukin-2 (IL-2) and IL-4 in the Regulation of Autonomous Growth and Tumorigenesis of Transformed Cells of Lymphoid Origin.
M. R. Hassuneh, P. S. Nagarkatti, and M. Nagarkatti (1997)
Blood 89, 610-620
   Abstract »    Full Text »    PDF »
Human T-cell Leukemia Virus Type I Tax Protein Transactivates RNA Polymerase III Promoter in Vitro and in Vivo.
G. Piras, J. Dittmer, M. F. Radonovich, and J. N. Brady (1996)
J. Biol. Chem. 271, 20501-20506
   Abstract »    Full Text »    PDF »
Human T-cell Leukemia Virus Type I Tax Masks c-Myc Function through a cAMP-dependent Pathway.
O. J. Semmes, J. F. Barrett, C. V. Dang, and K.-T. Jeang (1996)
J. Biol. Chem. 271, 9730-9738
   Abstract »    Full Text »    PDF »
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.
Y Iwakura, M Tosu, E Yoshida, M Takiguchi, K Sato, I Kitajima, K Nishioka, K Yamamoto, T Takeda, M Hatanaka, et al. (1991)
Science 253, 1026-1028
   Abstract »    PDF »
Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes..
M R Smith and W C Greene (1990)
Genes & Dev. 4, 1875-1885
   Abstract »    PDF »
HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.
K. Jeang, S. Widen, O. Semmes 4th, and S. Wilson (1990)
Science 247, 1082-1084
   Abstract »    PDF »
HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene.
D. Ballard, E Bohnlein, J. Lowenthal, Y Wano, B. Franza, and W. Greene (1988)
Science 241, 1652-1655
   Abstract »    PDF »
Regulation of HIV and HTLV gene expression..
H Varmus (1988)
Genes & Dev. 2, 1055-1062
   PDF »
Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.
S Ruben, H Poteat, T. Tan, K Kawakami, R Roeder, W Haseltine, and C. Rosen (1988)
Science 241, 89-92
   Abstract »    PDF »
HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
J. Rosenblatt, A. Cann, D. Slamon, I. Smalberg, N. Shah, J Fujii, W Wachsman, and I. Chen (1988)
Science 240, 916-919
   Abstract »    PDF »
Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1.
M. Sadaie, T Benter, and F Wong-Staal (1988)
Science 239, 910-913
   Abstract »    PDF »
A quantitative bioassay for HIV-1 based on trans-activation.
B. Felber and G. Pavlakis (1988)
Science 239, 184-187
   Abstract »    PDF »
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.
M Nerenberg, S. Hinrichs, R. Reynolds, G Khoury, and G Jay (1987)
Science 237, 1324-1329
   Abstract »    PDF »
U3 sequences from HTLV-I and -II LTRs confer pX protein response to a murine leukemia virus LTR.
H Kitado, I. Chen, N. Shah, A. Cann, K Shimotohno, and H Fan (1987)
Science 235, 901-904
   Abstract »    PDF »
HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
W Wachsman, A. Cann, J. Williams, D. Slamon, L Souza, N. Shah, and I. Chen (1987)
Science 235, 674-677
   Abstract »    PDF »
Expression and characterization of the trans-activator of HTLV-III/LAV virus.
C. Wright, B. Felber, H Paskalis, and G. Pavlakis (1986)
Science 234, 988-992
   Abstract »    PDF »
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)