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Science 16 August 1985:
Vol. 229. no. 4714, pp. 658 - 661
DOI: 10.1126/science.3895435
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Articles

Science, Vol 229, Issue 4714, 658-661
Copyright © 1985 by American Association for the Advancement of Science

articles

Chromosome-sized DNA molecules of Plasmodium falciparum

LH Van der Ploeg, M Smits, T Ponnudurai, A Vermeulen, JH Meuwissen, and G Langsley

At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic analysis of the human malaria parasite Plasmodium falciparum.
D Walliker, I. Quakyi, T. Wellems, T. McCutchan, A Szarfman, W. London, L. Corcoran, T. Burkot, and R Carter (1987)
Science 236, 1661-1666
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Karyotype analysis of Leishmania species and its use in classification and clinical diagnosis.
S. Giannini, M Schittini, J. Keithly, P. Warburton, C. Cantor, and L. Van der Ploeg (1986)
Science 232, 762-765
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Electrophoretic separations of large DNA molecules by periodic inversion of the electric field.
G. Carle, M Frank, and M. Olson (1986)
Science 232, 65-68
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