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Science 9 August 1985:
Vol. 229. no. 4713, pp. 563 - 566
DOI: 10.1126/science.2992081

Articles

Science, Vol 229, Issue 4713, 563-566
Copyright © 1985 by American Association for the Advancement of Science


articles

Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

S Harada, Y Koyanagi, and N Yamamoto

The human T-cell lines MT-2 and MT-4 carry the human T-cell leukemia virus type I (HTLV-I). When MT-2 and MT-4 were infected with HTLV-III, the probable etiologic agent of the acquired immune deficiency syndrome (AIDS), rapid cytopathogenic effects and cytotoxicity were observed that made it possible to titrate the biologically active virus in a plaque-forming assay. The cytopathogenic effects were preceded by the rapid induction and increase of HTLV-III antigens as revealed by immunofluorescence and immunoprecipitation. Activities of HTLV-III were neutralized by the human antibodies against the virus when immunofluorescence and plaque assays were used. Essentially the same results were obtained with the lymphadenopathy-associated virus (LAV1).


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J. Virol. 73, 6293-6298
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S. M. Philpott and G. C. Buehring (1999)
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Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1.
J. Martinez-Picado, A. V. Savara, L. Sutton, and R. T. D'Aquila (1999)
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Drastic Fitness Loss in Human Immunodeficiency Virus Type 1 upon Serial Bottleneck Events.
E. Yuste, S. Sanchez-Palomino, C. Casado, E. Domingo, and C. Lopez-Galindez (1999)
J. Virol. 73, 2745-2751
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Activity of Different Bicyclam Derivatives against Human Immunodeficiency Virus Depends on Their Interaction with the CXCR4 Chemokine Receptor.
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Prostaglandin E2 Up-regulates HIV-1 Long Terminal Repeat-driven Gene Activity in T Cells via NF-kappa B-dependent and -Independent Signaling Pathways.
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Differential Expression of Nur77 Family Members in Human T-Lymphotropic Virus Type 1-Infected Cells: Transactivation of the TR3/nur77 Gene by Tax Protein.
X. Chen, V. Zachar, C. Chang, P. Ebbesen, and X. Liu (1998)
J. Virol. 72, 6902-6906
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S-1153 Inhibits Replication of Known Drug-Resistant Strains of Human Immunodeficiency Virus Type 1.
T. Fujiwara, A. Sato, M. El-Farrash, S. Miki, K. Abe, Y. Isaka, M. Kodama, Y. Wu, L. B. Chen, H. Harada, et al. (1998)
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S. D. Kemp, C. Shi, S. Bloor, P. R. Harrigan, J. W. Mellors, and B. A. Larder (1998)
J. Virol. 72, 5093-5098
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Factors Secreted by Human T Lymphotropic Virus Type I (HTLV-I)-infected Cells Can Enhance or Inhibit Replication of HIV-1 in HTLV-I-uninfected Cells: Implications for In Vivo Coinfection with HTLV-I and HIV-1.
H. Moriuchi, M. Moriuchi, and A. S. Fauci (1998)
J. Exp. Med. 187, 1689-1697
   Abstract »    Full Text »    PDF »
T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1alpha Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use.
D. Schols, J. A. Este, C. Cabrera, and E. De Clercq (1998)
J. Virol. 72, 4032-4037
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The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells.
Z. Nie, D. Bergeron, R. A. Subbramanian, X.-J. Yao, F. Checroune, N. Rougeau, and E. A. Cohen (1998)
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Sequential Steps in Human Immunodeficiency Virus Particle Maturation Revealed by Alterations of Individual Gag Polyprotein Cleavage Sites.
K. Wiegers, G. Rutter, H. Kottler, U. Tessmer, H. Hohenberg, and H.-G. Krausslich (1998)
J. Virol. 72, 2846-2854
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Cleavage of Human Immunodeficiency Virus Type 1 Proteinase from the N-Terminally Adjacent p6* Protein Is Essential for Efficient Gag Polyprotein Processing and Viral Infectivity.
U. Tessmer and H.-G. Krausslich (1998)
J. Virol. 72, 3459-3463
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The Lipophosphoglycan of Leishmania donovani Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-{kappa}B Elements.
R. Bernier, B. Barbeau, M. J. Tremblay, and M. Olivier (1998)
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Evidence that Antibody-Mediated Neutralization of Human Immunodeficiency Virus Type 1 by Sera from Infected Individuals Is Independent of Coreceptor Usage.
D. C. Montefiori, R. G. Collman, T. R. Fouts, J. Y. Zhou, M. Bilska, J. A. Hoxie, J. P. Moore, and D. P. Bolognesi (1998)
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Amino Acid Analogs Activate NF-kappa B through Redox-dependent Ikappa B-alpha Degradation by the Proteasome without Apparent Ikappa B-alpha Phosphorylation. CONSEQUENCE ON HIV-1 LONG TERMINAL REPEAT ACTIVATION.
C. Kretz-Remy, E. E. M. Bates, and A.-P. Arrigo (1998)
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Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein.
C. A. Pise-Masison, K.-S. Choi, M. Radonovich, J. Dittmer, S.-J. Kim, and J. N. Brady (1998)
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Human Immunodeficiency Virus Glycoprotein gp120 as the Primary Target for the Antiviral Action of AR177 (Zintevir).
J. A. Esté, C. Cabrera, D. Schols, P. Cherepanov, A. Gutierrez, M. Witvrouw, C. Pannecouque, Z. Debyser, R. F. Rando, B. Clotet, et al. (1998)
Mol. Pharmacol. 53, 340-345
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The Acquisition of Host-Derived Major Histocompatibility Complex Class II Glycoproteins by Human Immunodeficiency Virus Type 1 Accelerates the Process of Virus Entry and Infection in Human T-Lymphoid Cells.
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UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-Acetylgalactosaminyltransferase.
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An internally controlled virion PCR for the measurement of HIV-1 RNA in plasma..
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A Patient With Progressive Myelopathy and Antibodies to Human T-Cell Leukemia Virus Type I and Human Immunodeficiency Virus Type 1 in Serum and Cerebrospinal Fluid.
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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).
B. Larder and S. Kemp (1989)
Science 246, 1155-1158
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Human T-Cell Lymphotropic Virus Type I (HTLV-I)-Associated Adult T-Cell Leukemia-Lymphoma in a Patient Infected with Human Immunodeficiency Virus Type 1 (HIV-1).
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Ann Intern Med 111, 871-875
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HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.
B. Larder, G Darby, and D. Richman (1989)
Science 243, 1731-1734
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Type-restricted neutralization of molecular clones of human immunodeficiency virus.
D. Looney, A. Fisher, S. Putney, Rusche JR, R. Redfield, D. Burke, R. Gallo, and F Wong-Staal (1988)
Science 241, 357-359
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Biologic features of HIV-1 that correlate with virulence in the host.
C Cheng-Mayer, D Seto, M Tateno, and J. Levy (1988)
Science 240, 80-82
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A quantitative bioassay for HIV-1 based on trans-activation.
B. Felber and G. Pavlakis (1988)
Science 239, 184-187
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Transmission of HTLV-I and HIV Among Homosexual Men in Trinidad.
C. Bartholomew, W. C. Saxinger, J. W. Clark, M. Gail, A. Dudgeon, B. Mahabir, B. Hull-Drysdale, F. Cleghorn, R. C. Gallo, and W. A. Blattner (1987)
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