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Science 9 August 1985:
Vol. 229. no. 4713, pp. 561 - 563
DOI: 10.1126/science.2410981
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Articles

Science, Vol 229, Issue 4713, 561-563
Copyright © 1985 by American Association for the Advancement of Science

articles

Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex

F Laure, D Zagury, AG Saimot, RC Gallo, BH Hahn, and C Brechot

A lymphotropic virus HTLV-III/LAV was recently identified as the etiologic agent of the acquired immune deficiency syndrome (AIDS). In a study of concomitant hepatitis B infections in patients with AIDS or the AIDS-related complex, DNA sequences of hepatitis B virus (HBV) were found in fresh and cultured lymphocytes from patients with AIDS even in the absence of conventional HBV serological markers. Furthermore, the restriction DNA pattern was consistent with the integration of the viral DNA. These results should prompt additional studies to reevaluate a possible role of HBV as a cofactor in AIDS in addition to the HTLV-III/LAV causal agent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Detection and Sequence Analysis of Hepatitis B Virus Integration in Peripheral Blood Mononuclear Cells.
T. Laskus, M. Radkowski, L.-F. Wang, M. Nowicki, and J. Rakela (1999)
J. Virol. 73, 1235-1238
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Unique Alterations of Thyroid Hormone Indices in the Acquired Immunodeficiency Syndrome (AIDS).
J. S. LoPresti, J. C. Fried, C. A. Spencer, and J. T. Nicoloff (1989)
Ann Intern Med 110, 970-975
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HIV Infection in the Dominican Republic.
W. R. Lange and S. D. Kreider (1987)
JAMA 258, 46
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Serologic and Immunologic Studies in Patients With AIDS in North America and Africa: The Potential Role of Infectious Agents as Cofactors in Human Immunodeficiency Virus Infection.
T. C. Quinn, P. Piot, J. B. McCormick, F. M. Feinsod, H. Taelman, B. Kapita, W. Stevens, and A. S. Fauci (1987)
JAMA 257, 2617-2621
   Abstract »    PDF »
The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals. FUNCTIONAL ROLES OF NF-kappa B/NF-AT AND SP1-BINDING SITES IN THE HIV-1 LONG TERMINAL REPEAT PROMOTER.
M. Gomez-Gonzalo, M. Carretero, J. Rullas, E. Lara-Pezzi, J. Aramburu, B. Berkhout, J. Alcami, and M. Lopez-Cabrera (2001)
J. Biol. Chem. 276, 35435-35443
   Abstract »    Full Text »    PDF »


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