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Science 9 August 1985:
Vol. 229. no. 4713, pp. 528 - 534
DOI: 10.1126/science.3927483
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Articles

Science, Vol 229, Issue 4713, 528-534
Copyright © 1985 by American Association for the Advancement of Science

articles

Active T-cell receptor genes have intron deoxyribonuclease hypersensitive sites

E Bier, Y Hashimoto, MI Greene, and AM Maxam

The T-cell receptor beta-chain gene has a nuclease hypersensitive site in several kinds of T cells, which does not appear in B cells expressing immunoglobulins. Conversely, the kappa immunoglobulin gene shows a known hypersensitive site at its enhancer element in B cells, as expected, but this site is absent in T cells. As is the case with immunoglobulin genes, the T-cell receptor site lies within the gene, in the intron separating joining and constant region segments. These nuclease hypersensitive DNA configurations in the introns of active T-cell receptor and immunoglobulin genes may arise from control elements that share ancestry but have diverged to the extent that each normally acts only in lymphoid cells which use the proximal gene product.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B..
J Hagman, C M Rudin, D Haasch, D Chaplin, and U Storb (1990)
Genes & Dev. 4, 978-992
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A transcriptional enhancer 3' of C beta 2 in the T cell receptor beta locus.
S McDougall, C. Peterson, and K Calame (1988)
Science 241, 205-208
   Abstract »    PDF »


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