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Science 2 August 1985:
Vol. 229. no. 4712, pp. 479 - 481
DOI: 10.1126/science.2409603
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Articles

Science, Vol 229, Issue 4712, 479-481
Copyright © 1985 by American Association for the Advancement of Science

articles

Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women

AV Muchmore and JM Decker

Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.


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