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Science 2 August 1985:
Vol. 229. no. 4712, pp. 475 - 479
DOI: 10.1126/science.3160115
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Articles

Science, Vol 229, Issue 4712, 475-479
Copyright © 1985 by American Association for the Advancement of Science

articles

Protein-specific helper T-lymphocyte formation initiated by dendritic cells

K Inaba and RM Steinman

Antibody responses to hapten-polypeptide conjugates require peptide-specific helper T cells. The latter can be primed in tissue culture by providing small numbers of dendritic cells. Primed, irradiated helper T cells then induce B-cell growth and differentiation in the apparent absence of dendritic cells. Both stages of the antibody response--the induction of helper T lymphoblasts by dendritic cells and the delivery of help from T to B cell--occur in discrete cell aggregates that can be isolated by velocity sedimentation. If helper T blasts revert to smaller "memory" lymphocytes, dendritic cells again are needed to initiate the antibody response.


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