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Science 19 July 1985:
Vol. 229. no. 4710, pp. 275 - 277
DOI: 10.1126/science.3160113
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Articles
Science, Vol 229, Issue 4710, 275-277
Copyright © 1985 by American Association for the Advancement of Science
Presence of laminin receptors in Staphylococcus aureus
JD Lopes,
M dos Reis,
and
RR Brentani
A characteristic feature of infection by Staphylococcus aureus is bloodstream invasion and widespread metastatic abscess formation. The ability to extravasate, which entails crossing the vascular basement membrane, appears to be critical for the organism's pathogenicity. Extravasation by normal and neoplastic mammalian cells has been correlated with the presence of specific cell surface receptors for the basement membrane glycoprotein laminin. Similar laminin receptors were found in Staphylococcus aureus but not in Staphylococcus epidermidis, a noninvasive pathogen. There were about 100 binding sites per cell, with an apparent binding affinity of 2.9 nanomolar. The molecular weight of the receptor was 50,000 and pI was 4.2. Eukaryotic laminin receptors were visualized by means of the binding of S. aureus in the presence of laminin. Prokaryotic and eukaryotic invasive cells might utilize similar, if not identical, mechanisms for invasion.
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