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Science 12 July 1985:
Vol. 229. no. 4709, pp. 190 - 193
DOI: 10.1126/science.3892689
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Articles

Science, Vol 229, Issue 4709, 190-193
Copyright © 1985 by American Association for the Advancement of Science

articles

Expression of two variant surface glycoproteins on individual African trypanosomes during antigen switching

KM Esser and MJ Schoenbechler

Individual Trypanosoma brucei rhodesiense organisms were observed in the process of switching variant surface glycoproteins (VSG's). During this switch, trypanosomes simultaneously expressed both pre- and postswitch VSG's uniformly over their surface as detected with monoclonal antibodies. Analysis of this switching event showed that trypanosomes expressing any one of three distinct preswitch VSG's could switch to expression of from one to three different postswitch VSG's. Up to 2.7 percent of the trypanosome population was in the process of switching at one time.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Trypanosomes Expressing a Mosaic Variant Surface Glycoprotein Coat Escape Early Detection by the Immune System.
M. E. Dubois, K. P. Demick, and J. M. Mansfield (2005)
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Variant-Specific Surface Protein Switching in Giardia lamblia.
T. E. Nash, H. T. Lujan, M. R. Mowatt, and J. T. Conrad (2001)
Infect. Immun. 69, 1922-1923
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Leaky Transcription of Variant Surface Glycoprotein Gene Expression Sites in Bloodstream African Trypanosomes.
C. M. Alarcon, M. Pedram, and J. E. Donelson (1999)
J. Biol. Chem. 274, 16884-16893
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Cell lysis induces redistribution of the GPI-anchored variant surface glycoprotein on both faces of the plasma membrane of Trypanosoma brucei.
M. Cardoso De Almeida, M Geuskens, and E Pays (1999)
J. Cell Sci. 112, 4461-4473
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The GPI-Phospholipase C of Trypanosoma brucei Is Nonessential But Influences Parasitemia in Mice.
H. Webb, N. Carnall, L. Vanhamme, S. Rolin, J. V. D. Abbeele, S. Welburn, E. Pays, and M. Carrington (1997)
J. Cell Biol. 139, 103-114
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Mechanisms of Antigenic Variation in Borrelia hermsii and African Trypanosomes.
J. E. Donelson and J. E. Donelson (1995)
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