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Science 12 July 1985:
Vol. 229. no. 4709, pp. 176 - 179
DOI: 10.1126/science.3160110
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Articles

Science, Vol 229, Issue 4709, 176-179
Copyright © 1985 by American Association for the Advancement of Science

articles

Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo

S Landolfo, F Cofano, M Giovarelli, M Prat, G Cavallo, and G Forni

The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-gamma abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Combined Allogeneic Tumor Cell Vaccination and Systemic Interleukin 12 Prevents Mammary Carcinogenesis in HER-2/neu Transgenic Mice.
P. Nanni, G. Nicoletti, C. De Giovanni, L. Landuzzi, E. Di Carlo, F. Cavallo, S. M. Pupa, I. Rossi, M. P. Colombo, C. Ricci, et al. (2001)
J. Exp. Med. 194, 1195-1206
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Interleukin 12-activated Lymphocytes Influence Tumor Genetic Programs.
F. Cavallo, E. Quaglino, L. Cifaldi, E. Di Carlo, A. André, P. Bernabei, P. Musiani, G. Forni, and R. A. Calogero (2001)
Cancer Res. 61, 3518-3523
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Vaccination with Mouse Mammary Adenocarcinoma Cells Coexpressing B7-1 (CD80) and B7-2 (CD86) Discloses the Dominant Effect of B7-1 in the Induction of Antitumor Immunity.
A. Martin-Fontecha, M. Moro, M. C. Crosti, F. Veglia, G. Casorati, and P. Dellabona (2000)
J. Immunol. 164, 698-704
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Protective Role of {beta}-Chemokines Associated with HIV-Specific Th Responses Against Perinatal HIV Transmission.
T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, V. E. Whiteman, R. R. Rutstein, S. E. Starr, S. D. Douglas, D. Kaufman, A. V. Sison, M. Polansky, et al. (1999)
J. Immunol. 162, 4355-4364
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Evidence for a Role of IL-17 in Organ Allograft Rejection: IL-17 Promotes the Functional Differentiation of Dendritic Cell Progenitors.
M. A. Antonysamy, W. C. Fanslow, F. Fu, W. Li, S. Qian, A. B. Troutt, and A. W. Thomson (1999)
J. Immunol. 162, 577-584
   Abstract »    Full Text »    PDF »
Interferon-gamma Increases Expression of Chemokine Receptors CCR1, CCR3, and CCR5, But Not CXCR4 in Monocytoid U937 Cells.
D. Zella, O. Barabitskaja, J. M. Burns, F. Romerio, D. E. Dunn, M. G. Revello, G. Gerna, M. S. R. Jr, R. C. Gallo, and F. F. Weichold (1998)
Blood 91, 4444-4450
   Abstract »    Full Text »    PDF »


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