Science 5 July 1985: Vol. 229. no. 4708, pp. 69 - 73 DOI: 10.1126/science.2990040

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HIV-1 Tat Mediates Degradation of RON Receptor Tyrosine Kinase, a Regulator of Inflammation.

P. Kalantari, O. F. Harandi, P. A. Hankey, and A. J. Henderson (2008)
J. Immunol. 181, 1548-1555
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Hydroxyurea and Interleukin-6 Synergistically Reactivate HIV-1 Replication in a Latently Infected Promonocytic Cell Line via SP1/SP3 Transcription Factors.

R. M. Oguariri, T. W. Brann, and T. Imamichi (2007)
J. Biol. Chem. 282, 3594-3604
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Is a Natively Unfolded Protein: THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 Tat-(1-72) BY NMR SPECTROSCOPY.

S. Shojania and J. D. O'Neil (2006)
J. Biol. Chem. 281, 8347-8356
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The C Terminus of HIV-1 Tat Modulates the Extent of CD178-mediated Apoptosis of T Cells.

G. R. Campbell, J. D. Watkins, D. Esquieu, E. Pasquier, E. P. Loret, and S. A. Spector (2005)
J. Biol. Chem. 280, 38376-38382
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Robust Growth of Human Immunodeficiency Virus Type 1 (HIV-1).

H. Kim and J. Yin (2005)
Biophys. J. 89, 2210-2221
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Induction of Neutralizing Antibodies and Th1-Polarized and CD4-Independent CD8+ T-Cell Responses following Delivery of Human Immunodeficiency Virus Type 1 Tat Protein by Recombinant Adenylate Cyclase of Bordetella pertussis.

L. Mascarell, C. Fayolle, C. Bauche, D. Ladant, and C. Leclerc (2005)
J. Virol. 79, 9872-9884
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Frequent Dual Initiation in Human Immunodeficiency Virus-Based Vectors Containing Two Primer-Binding Sites: a Quantitative In Vivo Assay for Function of Initiation Complexes.

Y. A. Voronin and V. K. Pathak (2004)
J. Virol. 78, 5402-5413
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Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine.

G. Voss, K. Manson, D. Montefiori, D. I. Watkins, J. Heeney, M. Wyand, J. Cohen, and C. Bruck (2002)
J. Virol. 77, 1049-1058
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RNA Incorporation Is Critical for Retroviral Particle Integrity after Cell Membrane Assembly of Gag Complexes.

S.-W. Wang and A. Aldovini (2002)
J. Virol. 76, 11853-11865
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Physical and Functional Interaction of HIV-1 Tat with E2F-4, a Transcriptional Regulator of Mammalian Cell Cycle.

C. Ambrosino, C. Palmieri, A. Puca, F. Trimboli, M. Schiavone, F. Olimpico, M. R. Ruocco, F. di Leva, M. Toriello, I. Quinto, et al. (2002)
J. Biol. Chem. 277, 31448-31458
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Angiogenic Effects of Extracellular Human Immunodeficiency Virus Type 1 Tat Protein and Its Role in the Pathogenesis of AIDS-Associated Kaposi's Sarcoma.

G. Barillari and B. Ensoli (2002)
Clin. Microbiol. Rev. 15, 310-326
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Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein.

P. Silvera, M. W. Richardson, J. Greenhouse, J. Yalley-Ogunro, N. Shaw, J. Mirchandani, K. Khalili, J.-F. Zagury, M. G. Lewis, and J. Rappaport (2002)
J. Virol. 76, 3800-3809
 |  Abstract »  |  Full Text »  |  PDF »

Native HIV-1 Tat Protein Targets Monocyte-Derived Dendritic Cells and Enhances Their Maturation, Function, and Antigen-Specific T Cell Responses.

E. Fanales-Belasio, S. Moretti, F. Nappi, G. Barillari, F. Micheletti, A. Cafaro, and B. Ensoli (2002)
J. Immunol. 168, 197-206
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Activation of Matrix-Metalloproteinase-2 and Membrane-Type-1-Matrix-Metalloproteinase in Endothelial Cells and Induction of Vascular Permeability In Vivo by Human Immunodeficiency Virus-1 Tat Protein and Basic Fibroblast Growth Factor.

E. Toschi, G. Barillari, C. Sgadari, I. Bacigalupo, A. Cereseto, D. Carlei, C. Palladino, C. Zietz, P. Leone, M. Sturzl, et al. (2001)
Mol. Biol. Cell 12, 2934-2946
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RNA Trafficking Signals in Human Immunodeficiency Virus Type 1.

A. J. Mouland, H. Xu, H. Cui, W. Krueger, T. P. Munro, M. Prasol, J. Mercier, D. Rekosh, R. Smith, E. Barbarese, et al. (2001)
Mol. Cell. Biol. 21, 2133-2143
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Human Kaposi's Sarcoma Cell-Mediated Tumorigenesis in Human Immunodeficiency Type 1 Tat-Expressing Transgenic Mice.

O. Prakash, Z.-Y. Tang, Y.-e He, M. S. Ali, R. Coleman, J. Gill, G. Farr, and F. Samaniego (2000)
J Natl Cancer Inst 92, 721-728
 |  Abstract »  |  Full Text »  |  PDF »

Jembrana Disease Virus Tat Can Regulate Human Immunodeficiency Virus (HIV) Long Terminal Repeat-Directed Gene Expression and Can Substitute for HIV Tat in Viral Replication.

H. Chen, J. He, S. Fong, G. Wilcox, and C. Wood (2000)
J. Virol. 74, 2703-2713
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Molecular Cloning of a Novel Human I-mfa Domain-containing Protein That Differently Regulates Human T-cell Leukemia Virus Type I and HIV-1 Expression.

S. Thebault, F. Gachon, I. Lemasson, C. Devaux, and J.-M. Mesnard (2000)
J. Biol. Chem. 275, 4848-4857
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The Human Immunodeficiency Virus Type 1 Tat Protein Up-Regulates the Promoter Activity of the Beta-Chemokine Monocyte Chemoattractant Protein 1 in the Human Astrocytoma Cell Line U-87 MG: Role of SP-1, AP-1, and NF-kappa B Consensus Sites.

S. P. Lim and A. Garzino-Demo (2000)
J. Virol. 74, 1632-1640
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A Second Target for the Peptoid Tat/Transactivation Response Element Inhibitor CGP64222: Inhibition of Human Immunodeficiency Virus Replication by Blocking CXC-Chemokine Receptor 4-Mediated Virus Entry.

D. Daelemans, D. Schols, M. Witvrouw, C. Pannecouque, S. Hatse, S. van Dooren, F. Hamy, T. Klimkait, E. de Clercq, and A.-M. VanDamme (2000)
Mol. Pharmacol. 57, 116-124
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Replication-deficient recombinant adenoviruses expressing the human immunodeficiency virus Env antigen can induce both humoral and CTL immune responses in mice.

C. B. Bruce, A. Akrigg, S. A. Sharpe, T. Hanke, G. W. G. Wilkinson, and M. P. Cranage (1999)
J. Gen. Virol. 80, 2621-2628
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Potent Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Gene Expression and Virus Production by an HIV-2 Tat Activation-Response RNA Decoy.

C. M. Browning, L. Cagnon, P. D. Good, J. Rossi, D. R. Engelke, and D. M. Markovitz (1999)
J. Virol. 73, 5191-5195
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An Intact TAR Element and Cytoplasmic Localization Are Necessary for Efficient Packaging of Human Immunodeficiency Virus Type 1 Genomic RNA.

C. Helga-Maria, M.-L. Hammarskjöld, and D. Rekosh (1999)
J. Virol. 73, 4127-4135
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Requirements for Efficient Production and Transduction of Human Immunodeficiency Virus Type 1-Based Vectors.

M. Gasmi, J. Glynn, M.-J. Jin, D. J. Jolly, J.-K. Yee, and S.-T. Chen (1999)
J. Virol. 73, 1828-1834
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The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists.

M. Rusnati, G. Tulipano, C. Urbinati, E. Tanghetti, R. Giuliani, M. Giacca, M. Ciomei, A. Corallini, and M. Presta (1998)
J. Biol. Chem. 273, 16027-16037
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Microbial Conversion Products of Leptomycin B.

M. Kuhnt, F. Bitsch, M. Ponelle, J.-J. Sanglier, Y. Wang, and B. Wolff (1998)
Appl. Envir. Microbiol. 64, 714-720
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Nuclear Targeted Suppression of NF-{kappa}B Activity by the Novel Quinone Derivative E3330.

M. Hiramoto, N. Shimizu, K. Sugimoto, J. Tang, Y. Kawakami, M. Ito, S. Aizawa, H. Tanaka, I. Makino, and H. Handa (1998)
J. Immunol. 160, 810-819
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S-Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type 1 through Inhibition of the LTR Transactivation.

D. Daelemans, J. A. Esté, M. Witvrouw, C. Pannecouque, H. Jonckheere, S. Aquaro, C.-F. Perno, E. D. Clercq, and A.-M. Vandamme (1997)
Mol. Pharmacol. 52, 1157-1163
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HIV-1 Tat Induces the Expression of the Interleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting with CAAT Enhancer-binding Protein beta  (NF-IL6) Transcription Factors.

C. Ambrosino, M. R. Ruocco, X. Chen, M. Mallardo, F. Baudi, S. Trematerra, I. Quinto, S. Venuta, and G. Scala (1997)
J. Biol. Chem. 272, 14883-14892
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Interaction of HIV-1 Tat Protein with Heparin. ROLE OF THE BACKBONE STRUCTURE, SULFATION, AND SIZE.

M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini, D. Noonan, F. d'A. di Fagagna, M. Giacca, and M. Presta (1997)
J. Biol. Chem. 272, 11313-11320
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The Tat Protein of Human Immunodeficiency Virus Type 1Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR.

S. R. Brand, R. Kobayashi, and M. B. Mathews (1997)
J. Biol. Chem. 272, 8388-8395
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A simple method for measurement of cell-substrate attachment forces: application to HIV-1 Tat.

L. Channavajjala, A Eidsath, and W. Saxinger (1997)
J. Cell Sci. 110, 249-256
 |  Abstract »  |  PDF »

Conformational Heterogeneity in Two Regions of TAT Results in Structural Variations of This Protein as a Function of HIV-1 Isolates.

C. J. Gregoire and E. P. Loret (1996)
J. Biol. Chem. 271, 22641-22646
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Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist.

M. Hsu, A. Schutt, M Holly, L. Slice, M. Sherman, D. Richman, M. Potash, and D. Volsky (1991)
Science 254, 1799-1802
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Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs..

S J Arrigo and I S Chen (1991)
Genes & Dev. 5, 808-819
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Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition..

B J Calnan, S Biancalana, D Hudson, and A D Frankel (1991)
Genes & Dev. 5, 201-210
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Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation..

M F Laspia, A P Rice, and M B Mathews (1990)
Genes & Dev. 4, 2397-2408
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A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator.

P Nelbock, P. Dillon, A Perkins, and C. Rosen (1990)
Science 248, 1650-1653
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Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product.

S Roy, M. Katze, N. Parkin, I Edery, A. Hovanessian, and N Sonenberg (1990)
Science 247, 1216-1219
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Secondary structure is the major determinant for interaction of HIV rev protein with RNA.

H. Olsen, P Nelbock, A. Cochrane, and C. Rosen (1990)
Science 247, 845-848
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Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses.

P Lusso, F di Marzo Veronese, B Ensoli, G Franchini, C Jemma, S. DeRocco, V. Kalyanaraman, and R. Gallo (1990)
Science 247, 848-852
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Differential effects of nef on HIV replication: implications for viral pathogenesis in the host.

C Cheng-Mayer, P Iannello, K Shaw, P. Luciw, and J. Levy (1989)
Science 246, 1629-1632
 |  Abstract »  |  PDF »

Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells.

C. Hart, C. Ou, J. Galphin, J Moore, L. Bacheler, J. Wasmuth, S. Petteway Jr, and G Schochetman (1989)
Science 246, 488-491
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Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat..

M J Selby, E S Bain, P A Luciw, and B M Peterlin (1989)
Genes & Dev. 3, 547-558
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Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR.

N Ahmad and S Venkatesan (1988)
Science 241, 1481-1485
 |  Abstract »  |  PDF »

Virus-specific splicing inhibitor in extracts from cells infected with HIV-1.

D Gutman and C. Goldenberg (1988)
Science 241, 1492-1495
 |  Abstract »  |  PDF »

Regulation of HIV and HTLV gene expression..

H Varmus (1988)
Genes & Dev. 2, 1055-1062
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Structural arrangements of transcription control domains within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters..

K A Jones, P A Luciw, and N Duchange (1988)
Genes & Dev. 2, 1101-1114
 |  Abstract »  |  PDF »

Tat protein from human immunodeficiency virus forms a metal-linked dimer.

A. Frankel, D. Bredt, and C. Pabo (1988)
Science 240, 70-73
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Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1.

M. Sadaie, T Benter, and F Wong-Staal (1988)
Science 239, 910-913
 |  Abstract »  |  PDF »

The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.

A. Fauci (1988)
Science 239, 617-622
 |  Abstract »  |  PDF »

A quantitative bioassay for HIV-1 based on trans-activation.

B. Felber and G. Pavlakis (1988)
Science 239, 184-187
 |  Abstract »  |  PDF »

The sor gene of HIV-1 is required for efficient virus transmission in vitro.

A. Fisher, B Ensoli, L Ivanoff, M Chamberlain, S Petteway, L Ratner, R. Gallo, and F Wong-Staal (1987)
Science 237, 888-893
 |  Abstract »  |  PDF »

Expression of the art/trs protein of HIV and study of its role in viral envelope synthesis.

D. Knight, F. Flomerfelt, and J Ghrayeb (1987)
Science 236, 837-840
 |  Abstract »  |  PDF »

Expression and processing of the AIDS virus reverse transcriptase in Escherichia coli.

W. Farmerie, D. Loeb, N. Casavant, C. Hutchison 3rd, M. Edgell, and R Swanstrom (1987)
Science 236, 305-308
 |  Abstract »  |  PDF »

Expression and characterization of the trans-activator of HTLV-III/LAV virus.

C. Wright, B. Felber, H Paskalis, and G. Pavlakis (1986)
Science 234, 988-992
 |  Abstract »  |  PDF »

Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects.

A. Fisher, L Ratner, H Mitsuya, L. Marselle, M. Harper, S Broder, R. Gallo, and F Wong-Staal (1986)
Science 233, 655-659
 |  Abstract »  |  PDF »

Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.

K. Jones, J. Kadonaga, P. Luciw, and R Tjian (1986)
Science 232, 755-759
 |  Abstract »  |  PDF »

A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses.

T. Lee, J. Coligan, J. Allan, M. McLane, J. Groopman, and M Essex (1986)
Science 231, 1546-1549
 |  Abstract »  |  PDF »

Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.

J Sodroski, W. Goh, C Rosen, A Tartar, D Portetelle, A Burny, and W Haseltine (1986)
Science 231, 1549-1553
 |  Abstract »  |  PDF »

Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera.

N. Kan, G Franchini, F Wong-Staal, G. DuBois, W. Robey, J. Lautenberger, and T. Papas (1986)
Science 231, 1553-1555
 |  Abstract »  |  PDF »

Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.

D Zagury, J Bernard, R Leonard, R Cheynier, M Feldman, P. Sarin, and R. Gallo (1986)
Science 231, 850-853
 |  Abstract »  |  PDF »

The action of oncogenes in the cytoplasm and nucleus.

R. Weinberg (1985)
Science 230, 770-776
 |  Abstract »  |  PDF »

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.

J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science 230, 810-813
 |  Abstract »  |  PDF »

Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.

A. Rabson, D. Daugherty, S Venkatesan, K. Boulukos, S. Benn, T. Folks, P Feorino, and M. Martin (1985)
Science 229, 1388-1390
 |  Abstract »  |  PDF »

Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
Science 229, 74-77
 |  Abstract »  |  PDF »

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